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Thin Nguyen

Thin Nguyen contributes to research discovery and scholarly infrastructure.

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Published work

5 published item(s)

preprint2026arXiv

BSO: Safety Alignment Is Density Ratio Matching

Aligning language models for both helpfulness and safety typically requires complex pipelines-separate reward and cost models, online reinforcement learning, and primal-dual updates. Recent direct preference optimization approaches simplify training but incorporate safety through ad-hoc modifications such as multi-stage procedures or heuristic margin terms, lacking a principled derivation. We show that the likelihood ratio of the optimal safe policy admits a closed-form decomposition that reduces safety alignment to a density ratio matching problem. Minimizing Bregman divergences between the data and model ratios yields Bregman Safety Optimization (BSO), a family of single-stage loss functions, each induced by a convex generator, that provably recover the optimal safe policy. BSO is both general and simple: it requires no auxiliary models, introduces only one hyperparameter beyond standard preference optimization, and recovers existing safety-aware methods as special cases. Experiments across safety alignment benchmarks show that BSO consistently improves the safety-helpfulness trade-off.

preprint2022arXiv

Efficient Classification with Counterfactual Reasoning and Active Learning

Data augmentation is one of the most successful techniques to improve the classification accuracy of machine learning models in computer vision. However, applying data augmentation to tabular data is a challenging problem since it is hard to generate synthetic samples with labels. In this paper, we propose an efficient classifier with a novel data augmentation technique for tabular data. Our method called CCRAL combines causal reasoning to learn counterfactual samples for the original training samples and active learning to select useful counterfactual samples based on a region of uncertainty. By doing this, our method can maximize our model's generalization on the unseen testing data. We validate our method analytically, and compare with the standard baselines. Our experimental results highlight that CCRAL achieves significantly better performance than those of the baselines across several real-world tabular datasets in terms of accuracy and AUC. Data and source code are available at: https://github.com/nphdang/CCRAL.

preprint2022arXiv

Learning to Discover Medicines

Discovering new medicines is the hallmark of human endeavor to live a better and longer life. Yet the pace of discovery has slowed down as we need to venture into more wildly unexplored biomedical space to find one that matches today's high standard. Modern AI-enabled by powerful computing, large biomedical databases, and breakthroughs in deep learning-offers a new hope to break this loop as AI is rapidly maturing, ready to make a huge impact in the area. In this paper we review recent advances in AI methodologies that aim to crack this challenge. We organize the vast and rapidly growing literature of AI for drug discovery into three relatively stable sub-areas: (a) representation learning over molecular sequences and geometric graphs; (b) data-driven reasoning where we predict molecular properties and their binding, optimize existing compounds, generate de novo molecules, and plan the synthesis of target molecules; and (c) knowledge-based reasoning where we discuss the construction and reasoning over biomedical knowledge graphs. We will also identify open challenges and chart possible research directions for the years to come.

preprint2022arXiv

Mitigating cold start problems in drug-target affinity prediction with interaction knowledge transferring

Motivation: Predicting the drug-target interaction is crucial for drug discovery as well as drug repurposing. Machine learning is commonly used in drug-target affinity (DTA) problem. However, machine learning model faces the cold-start problem where the model performance drops when predicting the interaction of a novel drug or target. Previous works try to solve the cold start problem by learning the drug or target representation using unsupervised learning. While the drug or target representation can be learned in an unsupervised manner, it still lacks the interaction information, which is critical in drug-target interaction. Results: To incorporate the interaction information into the drug and protein interaction, we proposed using transfer learning from chemical-chemical interaction (CCI) and protein-protein interaction (PPI) task to drug-target interaction task. The representation learned by CCI and PPI tasks can be transferred smoothly to the DTA task due to the similar nature of the tasks. The result on the drug-target affinity datasets shows that our proposed method has advantages compared to other pretraining methods in the DTA task.

preprint2020arXiv

Deep Auto-Encoders with Sequential Learning for Multimodal Dimensional Emotion Recognition

Multimodal dimensional emotion recognition has drawn a great attention from the affective computing community and numerous schemes have been extensively investigated, making a significant progress in this area. However, several questions still remain unanswered for most of existing approaches including: (i) how to simultaneously learn compact yet representative features from multimodal data, (ii) how to effectively capture complementary features from multimodal streams, and (iii) how to perform all the tasks in an end-to-end manner. To address these challenges, in this paper, we propose a novel deep neural network architecture consisting of a two-stream auto-encoder and a long short term memory for effectively integrating visual and audio signal streams for emotion recognition. To validate the robustness of our proposed architecture, we carry out extensive experiments on the multimodal emotion in the wild dataset: RECOLA. Experimental results show that the proposed method achieves state-of-the-art recognition performance and surpasses existing schemes by a significant margin.