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Researcher profile

Tao Tan

Tao Tan contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Computer VisionArtificial Intelligence

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Published work

4 published item(s)

preprint2026arXiv

Conditional Diffusion Model with Anatomical-Dose Dual Constraints for End-to-End Multi-Tumor Dose Prediction

Radiotherapy treatment planning often relies on time-consuming, trial-and-error adjustments that heavily depend on the expertise of specialists, while existing deep learning methods face limitations in generalization, prediction accuracy, and clinical applicability. To tackle these challenges, we propose ADDiff-Dose, an Anatomical-Dose Dual Constraints Conditional Diffusion Model for end-to-end multi-tumor dose prediction. The model employs LightweightVAE3D to compress high-dimensional CT data and integrates multimodal inputs, including target and organ-at-risk (OAR) masks and beam parameters, within a progressive noise addition and denoising framework. It incorporates conditional features via a multi-head attention mechanism and utilizes a composite loss function combining MSE, conditional terms, and KL divergence to ensure both dosimetric accuracy and compliance with clinical constraints. Evaluation on a large-scale public dataset (2,877 cases) and three external institutional cohorts (450 cases in total) demonstrates that ADDiff-Dose significantly outperforms traditional baselines, achieving an MAE of 0.101-0.154 (compared to 0.316 for UNet and 0.169 for GAN models), a DICE coefficient of 0.927 (a 6.8% improvement), and limiting spinal cord maximum dose error to within 0.1 Gy. The average plan generation time per case is reduced to 22 seconds. Ablation studies confirm that the structural encoder enhances compliance with clinical dose constraints by 28.5%. To our knowledge, this is the first study to introduce a conditional diffusion model framework for radiotherapy dose prediction, offering a generalizable and efficient solution for automated treatment planning across diverse tumor sites, with the potential to substantially reduce planning time and improve clinical workflow efficiency.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

Diagnostic Performance of Universal-Learning Ultrasound AI Across Multiple Organs and Tasks: the UUSIC25 Challenge

IMPORTANCE: Modern ultrasound systems are universal diagnostic tools capable of imaging the entire body. However, current AI solutions remain fragmented into single-task tools. This critical gap between hardware versatility and software specificity limits workflow integration and clinical utility. OBJECTIVE: To evaluate the diagnostic accuracy, versatility, and efficiency of single general-purpose deep learning models for multi-organ classification and segmentation. DESIGN: The Universal UltraSound Image Challenge 2025 (UUSIC25) involved developing algorithms on 11,644 images aggregated from 12 sources (9 public, 3 private). Evaluation used an independent, multi-center private test set of 2,479 images, including data from a center completely unseen during training to assess generalization. OUTCOMES: Diagnostic performance (Dice Similarity Coefficient [DSC]; Area Under the Receiver Operating Characteristic Curve [AUC]) and computational efficiency (inference time, GPU memory). RESULTS: Of 15 valid algorithms, the top model (SMART) achieved a macro-averaged DSC of 0.854 across 5 segmentation tasks and AUC of 0.766 for binary classification. Models demonstrated high capability in anatomical segmentation (e.g., fetal head DSC: 0.942) but variability in complex diagnostic tasks subject to domain shift. Specifically, in breast cancer molecular subtyping, the top model's performance dropped from an AUC of 0.571 (internal) to 0.508 (unseen external center), highlighting the challenge of generalization. CONCLUSIONS: General-purpose AI models can achieve high accuracy and efficiency across multiple tasks using a single architecture. However, significant performance degradation on unseen data suggests domain generalization is critical for future clinical deployment.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

From Static Risk to Dynamic Trajectories: Toward World-Model-Inspired Clinical Prediction

Clinical decision-making is a feedback system where risk estimates influence treatment, which in turn changes disease trajectories, and both shape clinicians' measurement practices. Static prediction often fails clinically: models trained on observational care logs conflate disease biology with clinician behavior, particularly under treatment confounder feedback and irregular or informative observation. This Review focuses on intervention-aware disease trajectory modeling in clinical AI--methods estimating patient-specific longitudinal disease evolution and assessing trajectory changes under alternative treatments. We organize the field around six linked components: three decision tasks (factual forecasting, counterfactual estimation, policy evaluation) and three data-generating mechanisms (disease evolution, treatment assignment, observation process) that determine identifiability. We present the first unified framework bridging forecasting, counterfactual trajectories, and policy evaluation across discrete/continuous time, explicitly addressing treatment assignment, time-varying confounding, and observation bias. We synthesize key method families (multistate/joint models, temporal point-process, deep sequence architectures, longitudinal causal inference), map them to relevant components, and align evaluation with claim strength via overlap diagnostics, uncertainty quantification, off-policy robustness, and target-trial validation. This synthesis advances benchmark prediction to decision-grade clinical evidence, enabling treatment-sensitive individualized futures, pre-deployment policy stress-testing, and safer closed-loop learning health systems that adapt/abstain when evidence is insufficient.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

MoGen: A Unified Collaborative Framework for Controllable Multi-Object Image Generation

Existing multi-object image generation methods face difficulties in achieving precise alignment between localized image generation regions and their corresponding semantics based on language descriptions, frequently resulting in inconsistent object quantities and attribute aliasing. To mitigate this limitation, mainstream approaches typically rely on external control signals to explicitly constrain the spatial layout, local semantic and visual attributes of images. However, this strong dependency makes the input format rigid, rendering it incompatible with the heterogeneous resource conditions of users and diverse constraint requirements. To address these challenges, we propose MoGen, a user-friendly multi-object image generation method. First, we design a Regional Semantic Anchor (RSA) module that precisely anchors phrase units in language descriptions to their corresponding image regions during the generation process, enabling text-to-image generation that follows quantity specifications for multiple objects. Building upon this foundation, we further introduce an Adaptive Multi-modal Guidance (AMG) module, which adaptively parses and integrates various combinations of multi-source control signals to formulate corresponding structured intent. This intent subsequently guides selective constraints on scene layouts and object attributes, achieving dynamic fine-grained control. Experimental results demonstrate that MoGen significantly outperforms existing methods in generation quality, quantity consistency, and fine-grained control, while exhibiting superior accessibility and control flexibility. Code is available at: https://github.com/Tear-kitty/MoGen/tree/master.

0 citations0 reviewsNo code linkedOpen access