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Simon Arberet

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Published work

4 published item(s)

preprint2026arXiv

Any2Any 3D Diffusion Models with Knowledge Transfer: A Radiotherapy Planning Study

Voxel-wise dose prediction is a critical yet challenging task in practical radiotherapy (RT) planning, as bespoke models trained from scratch often struggle to generalize across diverse clinical settings. Meanwhile, generative models trained on billion-scale datasets from vision domains have achieved impressive performance. Herein, we propose DiffKT3D, a unified Any2Any 3D diffusion framework that leverages prior knowledge from pretrained video diffusion models for efficient and clinically meaningful dose prediction. To enable flexible conditioning across multiple clinical modalities (CT, anatomical structures, body, beam settings, etc.), we introduce an Any2Any conditional paradigm utilizing modality-specific embeddings without cross-attention overhead. Further, we design a novel reinforcement learning (RL) post-training mechanism guided by a clinically-informed Scorecard explicitly tailored to institutional treatment preferences. Compared with winner of GDP-HMM challenge, DiffKT3D sets a new state-of-the-art in dose prediction by reducing voxel-level MAE from 2.07 to 1.93. In addition, DiffKT3D achieves superior image quality and preference match. These results demonstrate that transferring diffusion priors via modality-aware conditioning and clinically aligned RL post-training can provide a robust and generalizable solution for RT planning across various clinical scenarios.

preprint2026arXiv

Learning to Optimize Radiotherapy Plans via Fluence Maps Diffusion Model Generation and LSTM-based Optimization

Volumetric Modulated Arc Therapy (VMAT) is a cornerstone of modern radiation therapy, enabling highly conformal tumor irradiation and healthy-tissue sparing. Yet, its planning solves inverse and nested optimization for multi-leaf collimators, monitor units and dose parameters, while enforcing their consistency to ensure mechanical deliverability. Nevertheless, this process often requires repeated re-optimization when treatment configurations change, resulting in substantial planning time per patient. To address these problems, we present a diffusion-driven Learning-to-Optimize (L2O) method for end-to-end VMAT planning. A distribution-matching distilled diffusion model learns a clinically feasible manifold of fluence maps, enabling their one-shot generation. On top of this, an LSTM-based L2O module learns gradient update dynamics to swiftly refine fluence maps toward prescribed dose objectives during inference. Experimental results on clinical and public prostate cancer cohorts demonstrate improved planning efficiency, flexibility, and machine deliverability over currently available end-to-end VMAT planners.

preprint2013arXiv

Reverberant Audio Source Separation via Sparse and Low-Rank Modeling

The performance of audio source separation from underdetermined convolutive mixture assuming known mixing filters can be significantly improved by using an analysis sparse prior optimized by a reweighting l1 scheme and a wideband datafidelity term, as demonstrated by a recent article. In this letter, we show that the performance can be improved even more significantly by exploiting a low-rank prior on the source spectrograms.We present a new algorithm to estimate the sources based on i) an analysis sparse prior, ii) a reweighting scheme so as to increase the sparsity, iii) a wideband data-fidelity term in a constrained form, and iv) a low-rank constraint on the source spectrograms. Evaluation on reverberant music mixtures shows that the resulting algorithm improves state-of-the-art methods by more than 2 dB of signal-to-distortion ratio.

preprint2012arXiv

Compressive Source Separation: Theory and Methods for Hyperspectral Imaging

With the development of numbers of high resolution data acquisition systems and the global requirement to lower the energy consumption, the development of efficient sensing techniques becomes critical. Recently, Compressed Sampling (CS) techniques, which exploit the sparsity of signals, have allowed to reconstruct signal and images with less measurements than the traditional Nyquist sensing approach. However, multichannel signals like Hyperspectral images (HSI) have additional structures, like inter-channel correlations, that are not taken into account in the classical CS scheme. In this paper we exploit the linear mixture of sources model, that is the assumption that the multichannel signal is composed of a linear combination of sources, each of them having its own spectral signature, and propose new sampling schemes exploiting this model to considerably decrease the number of measurements needed for the acquisition and source separation. Moreover, we give theoretical lower bounds on the number of measurements required to perform reconstruction of both the multichannel signal and its sources. We also proposed optimization algorithms and extensive experimentation on our target application which is HSI, and show that our approach recovers HSI with far less measurements and computational effort than traditional CS approaches.