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Qing Wu

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Published work

6 published item(s)

preprint2026arXiv

Disentangled Learning Improves Implicit Neural Representations for Medical Reconstruction

Implicit neural representations (INRs) have emerged as a powerful paradigm for medical imaging via physics-informed unsupervised learning. Classical INRs optimize an entire network from scratch for each subject, leading to inefficient training and suboptimal imaging quality. Recent initialization-based approaches attempt to inject population priors into pre-trained networks, yet they rely on high-quality images and often suffer from catastrophic forgetting during fine-tuning. We present DisINR, a novel INR framework that explicitly disentangles shared and subject-specific representations. DisINR introduces a shared encoder-decoder pair and subject-specific encoders, whose features are jointly decoded for image reconstruction. By integrating differentiable forward models, it pre-trains the shared modules directly from limited raw measurements, removing the need for pre-acquired high-quality images. During test-time adaptation, only the subject-specific encoder is optimized, while the shared pair remains frozen, effectively preserving learned priors. Extensive evaluations on three representative medical imaging tasks show that DisINR significantly outperforms state-of-the-art INRs in both reconstruction accuracy and efficiency.

preprint2022arXiv

Continuous longitudinal fetus brain atlas construction via implicit neural representation

Longitudinal fetal brain atlas is a powerful tool for understanding and characterizing the complex process of fetus brain development. Existing fetus brain atlases are typically constructed by averaged brain images on discrete time points independently over time. Due to the differences in onto-genetic trends among samples at different time points, the resulting atlases suffer from temporal inconsistency, which may lead to estimating error of the brain developmental characteristic parameters along the timeline. To this end, we proposed a multi-stage deep-learning framework to tackle the time inconsistency issue as a 4D (3D brain volume + 1D age) image data denoising task. Using implicit neural representation, we construct a continuous and noise-free longitudinal fetus brain atlas as a function of the 4D spatial-temporal coordinate. Experimental results on two public fetal brain atlases (CRL and FBA-Chinese atlases) show that the proposed method can significantly improve the atlas temporal consistency while maintaining good fetus brain structure representation. In addition, the continuous longitudinal fetus brain atlases can also be extensively applied to generate finer 4D atlases in both spatial and temporal resolution.

preprint2022arXiv

Noise2SR: Learning to Denoise from Super-Resolved Single Noisy Fluorescence Image

Fluorescence microscopy is a key driver to promote discoveries of biomedical research. However, with the limitation of microscope hardware and characteristics of the observed samples, the fluorescence microscopy images are susceptible to noise. Recently, a few self-supervised deep learning (DL) denoising methods have been proposed. However, the training efficiency and denoising performance of existing methods are relatively low in real scene noise removal. To address this issue, this paper proposed self-supervised image denoising method Noise2SR (N2SR) to train a simple and effective image denoising model based on single noisy observation. Our Noise2SR denoising model is designed for training with paired noisy images of different dimensions. Benefiting from this training strategy, Noise2SR is more efficiently self-supervised and able to restore more image details from a single noisy observation. Experimental results of simulated noise and real microscopy noise removal show that Noise2SR outperforms two blind-spot based self-supervised deep learning image denoising methods. We envision that Noise2SR has the potential to improve more other kind of scientific imaging quality.

preprint2020arXiv

Cross-Channel Intragroup Sparsity Neural Network

Modern deep neural networks rely on overparameterization to achieve state-of-the-art generalization. But overparameterized models are computationally expensive. Network pruning is often employed to obtain less demanding models for deployment. Fine-grained pruning removes individual weights in parameter tensors and can achieve a high model compression ratio with little accuracy degradation. However, it introduces irregularity into the computing dataflow and often does not yield improved model inference efficiency in practice. Coarse-grained model pruning, while realizing satisfactory inference speedup through removal of network weights in groups, e.g. an entire filter, often lead to significant accuracy degradation. This work introduces the cross-channel intragroup (CCI) sparsity structure, which can prevent the inference inefficiency of fine-grained pruning while maintaining outstanding model performance. We then present a novel training algorithm designed to perform well under the constraint imposed by the CCI-Sparsity. Through a series of comparative experiments we show that our proposed CCI-Sparsity structure and the corresponding pruning algorithm outperform prior art in inference efficiency by a substantial margin given suited hardware acceleration in the future.

preprint2016arXiv

A New Learning Method for Inference Accuracy, Core Occupation, and Performance Co-optimization on TrueNorth Chip

IBM TrueNorth chip uses digital spikes to perform neuromorphic computing and achieves ultrahigh execution parallelism and power efficiency. However, in TrueNorth chip, low quantization resolution of the synaptic weights and spikes significantly limits the inference (e.g., classification) accuracy of the deployed neural network model. Existing workaround, i.e., averaging the results over multiple copies instantiated in spatial and temporal domains, rapidly exhausts the hardware resources and slows down the computation. In this work, we propose a novel learning method on TrueNorth platform that constrains the random variance of each computation copy and reduces the number of needed copies. Compared to the existing learning method, our method can achieve up to 68.8% reduction of the required neuro-synaptic cores or 6.5X speedup, with even slightly improved inference accuracy.

preprint2014arXiv

Multiquark Cluster Form Factors In the Relativistic Harmonic Oscillator Model

A QCD multiquark cluster system is studied in the relativistic harmonic oscillator potential model (RHOPM), and the electromagnetic form factors of the pion, proton and deuteron in the RHOPM are predicted. The calculated theoretical results are then compared with existing experimental data, finding very good agreement between the theoretical predictions and experimental data for these three target particles. We claim that this model can be applied to study QCD hadronic properties, particularly neutron properties, and to find six-quark cluster and/or nine-quark cluster probabilities in light nuclei such as helium $^{3}He$ and tritium $^{3}H$. This is a problem of particular importance and interest in quark nuclear physics.