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Researcher profile

Nabeel Seedat

Nabeel Seedat contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Machine LearningArtificial IntelligenceComputer VisionComputation and Languageeess.SP

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Published work

7 published item(s)

preprint2026arXiv

To Whom Do Language Models Align? Measuring Principal Hierarchies Under High-Stakes Competing Demands

Language models deployed in high-stakes professional settings face conflicting demands from users, institutional authorities, and professional norms. How models act when these demands conflict reveals a principal hierarchy -- an implicit ordering over competing stakeholders that determines, for instance, whether a medical AI receiving a cost-reduction directive from a hospital administrator complies at the expense of evidence-based care, or refuses because professional standards require it. Across 7,136 scenarios in legal and medical domains, we test ten frontier models and find that models frequently fail to adhere to professional standards during task execution, such as drafting, when user instructions conflict with those standards -- despite adequately upholding them when users seek advisory guidance. We further find that the hierarchies between user, authority, and professional standards exhibited by these models are unstable across medical and legal contexts and inconsistent across model families. When failing to follow professional standards, the primary failure mechanism is knowledge omission: models that demonstrably possess relevant knowledge produce harmful outputs without surfacing conflicting knowledge. In a particularly troubling instance, we find that a reasoning model recognizes the relevant knowledge in its reasoning trace -- e.g., that a drug has been withdrawn -- yet suppresses this in the user-facing answer and proceeds to recommend the drug under authority pressure anyway. Inconsistent alignment across task framing, domain, and model families suggests that current alignment methods, including published alignment hierarchies, are unlikely to be robust when models are deployed in high-stakes professional settings.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Continuous-Time Modeling of Counterfactual Outcomes Using Neural Controlled Differential Equations

Estimating counterfactual outcomes over time has the potential to unlock personalized healthcare by assisting decision-makers to answer ''what-iF'' questions. Existing causal inference approaches typically consider regular, discrete-time intervals between observations and treatment decisions and hence are unable to naturally model irregularly sampled data, which is the common setting in practice. To handle arbitrary observation patterns, we interpret the data as samples from an underlying continuous-time process and propose to model its latent trajectory explicitly using the mathematics of controlled differential equations. This leads to a new approach, the Treatment Effect Neural Controlled Differential Equation (TE-CDE), that allows the potential outcomes to be evaluated at any time point. In addition, adversarial training is used to adjust for time-dependent confounding which is critical in longitudinal settings and is an added challenge not encountered in conventional time-series. To assess solutions to this problem, we propose a controllable simulation environment based on a model of tumor growth for a range of scenarios with irregular sampling reflective of a variety of clinical scenarios. TE-CDE consistently outperforms existing approaches in all simulated scenarios with irregular sampling.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Data-SUITE: Data-centric identification of in-distribution incongruous examples

Systematic quantification of data quality is critical for consistent model performance. Prior works have focused on out-of-distribution data. Instead, we tackle an understudied yet equally important problem of characterizing incongruous regions of in-distribution (ID) data, which may arise from feature space heterogeneity. To this end, we propose a paradigm shift with Data-SUITE: a data-centric AI framework to identify these regions, independent of a task-specific model. Data-SUITE leverages copula modeling, representation learning, and conformal prediction to build feature-wise confidence interval estimators based on a set of training instances. These estimators can be used to evaluate the congruence of test instances with respect to the training set, to answer two practically useful questions: (1) which test instances will be reliably predicted by a model trained with the training instances? and (2) can we identify incongruous regions of the feature space so that data owners understand the data's limitations or guide future data collection? We empirically validate Data-SUITE's performance and coverage guarantees and demonstrate on cross-site medical data, biased data, and data with concept drift, that Data-SUITE best identifies ID regions where a downstream model may be reliable (independent of said model). We also illustrate how these identified regions can provide insights into datasets and highlight their limitations.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Modeling Disagreement in Automatic Data Labelling for Semi-Supervised Learning in Clinical Natural Language Processing

Computational models providing accurate estimates of their uncertainty are crucial for risk management associated with decision making in healthcare contexts. This is especially true since many state-of-the-art systems are trained using the data which has been labelled automatically (self-supervised mode) and tend to overfit. In this work, we investigate the quality of uncertainty estimates from a range of current state-of-the-art predictive models applied to the problem of observation detection in radiology reports. This problem remains understudied for Natural Language Processing in the healthcare domain. We demonstrate that Gaussian Processes (GPs) provide superior performance in quantifying the risks of 3 uncertainty labels based on the negative log predictive probability (NLPP) evaluation metric and mean maximum predicted confidence levels (MMPCL), whilst retaining strong predictive performance.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Automated machine vision enabled detection of movement disorders from hand drawn spirals

A widely used test for the diagnosis of Parkinson's disease (PD) and Essential tremor (ET) is hand-drawn shapes,where the analysis is observationally performed by the examining neurologist. This method is subjective and is prone to bias amongst different physicians. Due to the similarities in the symptoms of the two diseases, they are often misdiagnosed.Studies which attempt to automate the process typically use digitized input, where the tablet or specialized equipment are not affordable in many clinical settings. This study uses a dataset of scanned pen and paper drawings and a convolutional neural network (CNN) to perform classification between PD, ET and control subjects. The discrimination accuracy of PD from controls was 98.2%. The discrimination accuracy of PD from ET and from controls was 92%. An ablation study was conducted and indicated that correct hyper parameter optimization can increases the accuracy up to 4.33%. Finally, the study indicates the viability of using a CNN-enabled machine vision system to provide robust and accurate detection of movement disorders from hand drawn spirals.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Machine learning discrimination of Parkinson's Disease stages from walker-mounted sensors data

Clinical methods that assess gait in Parkinson's Disease (PD) are mostly qualitative. Quantitative methods necessitate costly instrumentation or cumbersome wearable devices, which limits their usability. Only few of these methods can discriminate different stages in PD progression. This study applies machine learning methods to discriminate six stages of PD. The data was acquired by low cost walker-mounted sensors in an experiment at a movement disorders clinic and the PD stages were clinically labeled. A large set of features, some unique to this study are extracted and three feature selection methods are compared using a multi-class Random Forest (RF) classifier. The feature subset selected by the Analysis of Variance (ANOVA) method provided performance similar to the full feature set: 93% accuracy and had significantly shorter computation time. Compared to PCA, this method also enabled clinical interpretability of the selected features, an essential attribute to healthcare applications. All selected-feature sets are dominated by information theoretic features and statistical features and offer insights into the characteristics of gait deterioration in PD. The results indicate a feasibility of machine learning to accurately classify PD severity stages from kinematic signals acquired by low-cost, walker-mounted sensors and implies a potential to aid medical practitioners in the quantitative assessment of PD progression. The study presents a solution to the small and noisy data problem, which is common in most sensor-based healthcare assessments.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

MCU-Net: A framework towards uncertainty representations for decision support system patient referrals in healthcare contexts

Incorporating a human-in-the-loop system when deploying automated decision support is critical in healthcare contexts to create trust, as well as provide reliable performance on a patient-to-patient basis. Deep learning methods while having high performance, do not allow for this patient-centered approach due to the lack of uncertainty representation. Thus, we present a framework of uncertainty representation evaluated for medical image segmentation, using MCU-Net which combines a U-Net with Monte Carlo Dropout, evaluated with four different uncertainty metrics. The framework augments this by adding a human-in-the-loop aspect based on an uncertainty threshold for automated referral of uncertain cases to a medical professional. We demonstrate that MCU-Net combined with epistemic uncertainty and an uncertainty threshold tuned for this application maximizes automated performance on an individual patient level, yet refers truly uncertain cases. This is a step towards uncertainty representations when deploying machine learning based decision support in healthcare settings.

0 citations0 reviewsNo code linkedOpen access