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Researcher profile

Maria Brbic

Maria Brbic contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Machine LearningComputer VisionArtificial Intelligenceq-bio.MNQuantitative Methods

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Published work

4 published item(s)

preprint2026arXiv

PACER: Acyclic Causal Discovery from Large-Scale Interventional Data

Inferring the structure of directed acyclic graphs (DAGs) from data is a central challenge in causal discovery, particularly in modern high-dimensional settings where large-scale interventional data are increasingly available. While interventional data can improve identifiability, existing methods remain limited by soft acyclicity constraints, leading to optimization over invalid cyclic graphs, numerical instability, and reduced scalability. We introduce PACER (Perturbation-driven Acyclic Causal Edge Recovery), a scalable framework for causal discovery that guarantees acyclicity by construction. PACER parameterizes a distribution over DAGs through a joint model of variable permutations and edge probabilities, enabling direct optimization over valid causal structures without surrogate penalties. The framework supports a unified likelihood-based treatment of observational and interventional data, flexible conditional density models, and the incorporation of structural prior knowledge. For linear-Gaussian mechanisms, we derive closed-form expressions for the expected interventional log-likelihood and its gradients, yielding substantial computational gains. Empirically, PACER matches or exceeds state-of-the-art methods on protein signaling and large-scale genetic perturbation benchmarks, while scaling efficiently to networks with thousands of variables and achieving up to two orders of magnitude speedups over penalty-based differentiable approaches. These results demonstrate that exact and scalable causal discovery from high-dimensional perturbation data is achievable through principled search space design.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

Unsupervised Process Reward Models

Process Reward Models (PRMs) are a powerful mechanism for steering large language model reasoning by providing fine-grained, step-level supervision. However, this effectiveness comes at a significant cost: PRMs require expert annotations for every reasoning step, making them costly and difficult to scale. Here, we propose a method for training unsupervised PRMs (uPRM) that requires no human supervision, neither at the level of step-by-step annotations nor through ground-truth verification of final answers. The key idea behind our approach is to define a scoring function, derived from LLM next-token probabilities, that jointly assesses candidate positions of first erroneous steps across a batch of reasoning trajectories. We demonstrate the effectiveness of uPRM across diverse scenarios: (i) uPRM achieves up to 15% absolute accuracy improvements over the LLM-as-a-Judge in identifying first erroneous steps on the ProcessBench dataset; (ii) as a verifier for test-time scaling, uPRM performs comparably to supervised PRMs and outperforms the majority voting baseline by up to 6.9%, and (iii) when used as a reward signal in reinforcement learning, uPRM enables more robust policy optimization throughout training compared to a supervised PRM trained using ground-truth labels. Overall, our results open a path toward scalable reward modeling for complex reasoning tasks.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Open-World Semi-Supervised Learning

A fundamental limitation of applying semi-supervised learning in real-world settings is the assumption that unlabeled test data contains only classes previously encountered in the labeled training data. However, this assumption rarely holds for data in-the-wild, where instances belonging to novel classes may appear at testing time. Here, we introduce a novel open-world semi-supervised learning setting that formalizes the notion that novel classes may appear in the unlabeled test data. In this novel setting, the goal is to solve the class distribution mismatch between labeled and unlabeled data, where at the test time every input instance either needs to be classified into one of the existing classes or a new unseen class needs to be initialized. To tackle this challenging problem, we propose ORCA, an end-to-end deep learning approach that introduces uncertainty adaptive margin mechanism to circumvent the bias towards seen classes caused by learning discriminative features for seen classes faster than for the novel classes. In this way, ORCA reduces the gap between intra-class variance of seen with respect to novel classes. Experiments on image classification datasets and a single-cell annotation dataset demonstrate that ORCA consistently outperforms alternative baselines, achieving 25% improvement on seen and 96% improvement on novel classes of the ImageNet dataset.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

Model-Agnostic Graph Regularization for Few-Shot Learning

In many domains, relationships between categories are encoded in the knowledge graph. Recently, promising results have been achieved by incorporating knowledge graph as side information in hard classification tasks with severely limited data. However, prior models consist of highly complex architectures with many sub-components that all seem to impact performance. In this paper, we present a comprehensive empirical study on graph embedded few-shot learning. We introduce a graph regularization approach that allows a deeper understanding of the impact of incorporating graph information between labels. Our proposed regularization is widely applicable and model-agnostic, and boosts the performance of any few-shot learning model, including fine-tuning, metric-based, and optimization-based meta-learning. Our approach improves the performance of strong base learners by up to 2% on Mini-ImageNet and 6.7% on ImageNet-FS, outperforming state-of-the-art graph embedded methods. Additional analyses reveal that graph regularizing models result in a lower loss for more difficult tasks, such as those with fewer shots and less informative support examples.

0 citations0 reviewsNo code linkedOpen access