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Junhyeok Lee

Junhyeok Lee contributes to research discovery and scholarly infrastructure.

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Published work

4 published item(s)

preprint2026arXiv

Hierarchical Perfusion Graphs for Tumor Heterogeneity Modeling in Glioma Molecular Subtyping

Precise molecular subtyping of gliomas, including isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion, directly guides surgical and therapeutic decisions, yet currently relies on invasive tissue sampling. Deep learning on structural MRI has emerged as a non-invasive alternative, but anatomy-only approaches cannot capture the hemodynamic signatures that distinguish molecular subtypes. Radiogenomics based on dynamic susceptibility contrast (DSC) MRI holds immense potential for non-invasively characterizing glioma molecular subtypes, yet clinical deployment has been hindered by inter-site variability and the limitations of voxel-wise analysis. We introduce HiPerfGNN, a framework that first learns discrete hemodynamic representations from raw time-intensity curves using a vector-quantized variational autoencoder (VQ-VAE). These quantized perfusion codes define coarse-level graph nodes representing functional tumor habitats, each of which is hierarchically subdivided into fine-level subregions guided by structural MRI. A hierarchical graph neural network then propagates information across scales for molecular prediction. On an internal cohort (n=475), the model achieved AUCs of 0.96 (IDH), 0.89 (1p/19q), and 0.84 (WHO grade), and maintained robust IDH performance (AUC 0.89) on an independent external cohort (n=397) without recalibration. Gradient-based saliency analysis confirms biologically grounded attention patterns aligned with known glioma pathophysiology. Our results demonstrate the added value of integrating perfusion dynamics into radiogenomic pipelines for glioma molecular subtyping. Code is available at https://github.com/janghana/HiPerfGNN.

preprint2026arXiv

Super Monotonic Alignment Search

Monotonic alignment search (MAS), introduced by Glow-TTS, is one of the most popular algorithm in text-to-speech to estimate unknown alignments between text and speech. Since this algorithm needs to search for the most probable alignment with dynamic programming by caching all possible paths, the time complexity of the algorithm is $O(T \times S)$, where $T$ is the length of text and $S$ is the length of speech representation. The authors of Glow-TTS run this algorithm on CPU, and while they mentioned it is difficult to parallelize, we found that MAS can be parallelized in text length dimension and CPU execution consumes an inordinate amount of time for inter-device copy. Therefore, we implemented a Triton kernel and PyTorch JIT script to accelerate MAS on GPU without inter-device copy. As a result, Super-MAS Triton kernel is up to 72 times faster in the extreme-length case. The code is available at https://github.com/supertone-inc/super-monotonic-align.

preprint2022arXiv

Query-Efficient and Scalable Black-Box Adversarial Attacks on Discrete Sequential Data via Bayesian Optimization

We focus on the problem of adversarial attacks against models on discrete sequential data in the black-box setting where the attacker aims to craft adversarial examples with limited query access to the victim model. Existing black-box attacks, mostly based on greedy algorithms, find adversarial examples using pre-computed key positions to perturb, which severely limits the search space and might result in suboptimal solutions. To this end, we propose a query-efficient black-box attack using Bayesian optimization, which dynamically computes important positions using an automatic relevance determination (ARD) categorical kernel. We introduce block decomposition and history subsampling techniques to improve the scalability of Bayesian optimization when an input sequence becomes long. Moreover, we develop a post-optimization algorithm that finds adversarial examples with smaller perturbation size. Experiments on natural language and protein classification tasks demonstrate that our method consistently achieves higher attack success rate with significant reduction in query count and modification rate compared to the previous state-of-the-art methods.

preprint2022arXiv

Talking Face Generation with Multilingual TTS

In this work, we propose a joint system combining a talking face generation system with a text-to-speech system that can generate multilingual talking face videos from only the text input. Our system can synthesize natural multilingual speeches while maintaining the vocal identity of the speaker, as well as lip movements synchronized to the synthesized speech. We demonstrate the generalization capabilities of our system by selecting four languages (Korean, English, Japanese, and Chinese) each from a different language family. We also compare the outputs of our talking face generation model to outputs of a prior work that claims multilingual support. For our demo, we add a translation API to the preprocessing stage and present it in the form of a neural dubber so that users can utilize the multilingual property of our system more easily.