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Researcher profile

Julia Ive

Julia Ive contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Computation and LanguageMachine LearningArtificial IntelligenceComputer VisionHuman-Computer Interaction

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Published work

7 published item(s)

preprint2026arXiv

Development and Evaluation of HopeBot: an LLM-based chatbot for structured and interactive PHQ-9 depression screening

Static tools like the Patient Health Questionnaire-9 (PHQ-9) effectively screen depression but lack interactivity and adaptability. We developed HopeBot, a chatbot powered by a large language model (LLM) that administers the PHQ-9 using retrieval-augmented generation and real-time clarification. In a within-subject study, 132 adults in the United Kingdom and China completed both self-administered and chatbot versions. Scores demonstrated strong agreement (ICC = 0.91; 45% identical). Among 75 participants providing comparative feedback, 71% reported greater trust in the chatbot, highlighting clearer structure, interpretive guidance, and a supportive tone. Mean ratings (0-10) were 8.4 for comfort, 7.7 for voice clarity, 7.6 for handling sensitive topics, and 7.4 for recommendation helpfulness; the latter varied significantly by employment status and prior mental-health service use (p < 0.05). Overall, 87.1% expressed willingness to reuse or recommend HopeBot. These findings demonstrate voice-based LLM chatbots can feasibly serve as scalable, low-burden adjuncts for routine depression screening.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

VolTA-3D: Self-Supervised Learning for Brain MRI using 3D Volumetric Token Alignment

Self-supervised learning (SSL) has advanced medical image analysis be enabling learning form large unlabelled data. However, in brain magnetic resonance imaging (MRI), most 3D models remain specialized for either segmentation of classification, limiting their ability to generalize across datasets, imaging protocols,, and downstream tasks. This lack of transferability constrains the clinical utility of 3D MRI models, despite the availability of unlabeled volumetric data. We present Volta-3D, a self-supervised 3D Vision Transformer framework designed to learn transferable volumetric representations. Volta-3D jointly aligns global class-style tokens and local patch tokens within a student-teacher paradigm and enforces fine-grained structural reconstruction. This combined global-local alignment addresses the limited semantic diversity and subtle anatomical characteristics of brain MRI, which challenges existing SSL approaches. We evaluate Volta-3D on multiple out-of-distribution downstream tasks, including hippocampal segmentation and classification of sex and Alzheimer's disease versus healthy controls. Across all tasks, representations learned by Volta-3D outperform randomly initialized baselines, demonstrating improved transferability and robustness under domain shift. Hence jointly enforcing global semantic consistency and local structural learning during pretraining enables broader concept learning from unlabeled brain MRI data. Overall VolTA-3D supports effective multi-task downstream performance with task-specific pertaining, a step towards generalizable and clinically viable 3D models.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Medical Scientific Table-to-Text Generation with Human-in-the-Loop under the Data Sparsity Constraint

Structured (tabular) data in the preclinical and clinical domains contains valuable information about individuals and an efficient table-to-text summarization system can drastically reduce manual efforts to condense this data into reports. However, in practice, the problem is heavily impeded by the data paucity, data sparsity and inability of the state-of-the-art natural language generation models (including T5, PEGASUS and GPT-Neo) to produce accurate and reliable outputs. In this paper, we propose a novel table-to-text approach and tackle these problems with a novel two-step architecture which is enhanced by auto-correction, copy mechanism and synthetic data augmentation. The study shows that the proposed approach selects salient biomedical entities and values from structured data with improved precision (up to 0.13 absolute increase) of copying the tabular values to generate coherent and accurate text for assay validation reports and toxicology reports. Moreover, we also demonstrate a light-weight adaptation of the proposed system to new datasets by fine-tuning with as little as 40\% training examples. The outputs of our model are validated by human experts in the Human-in-the-Loop scenario.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Modeling Disagreement in Automatic Data Labelling for Semi-Supervised Learning in Clinical Natural Language Processing

Computational models providing accurate estimates of their uncertainty are crucial for risk management associated with decision making in healthcare contexts. This is especially true since many state-of-the-art systems are trained using the data which has been labelled automatically (self-supervised mode) and tend to overfit. In this work, we investigate the quality of uncertainty estimates from a range of current state-of-the-art predictive models applied to the problem of observation detection in radiology reports. This problem remains understudied for Natural Language Processing in the healthcare domain. We demonstrate that Gaussian Processes (GPs) provide superior performance in quantifying the risks of 3 uncertainty labels based on the negative log predictive probability (NLPP) evaluation metric and mean maximum predicted confidence levels (MMPCL), whilst retaining strong predictive performance.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Unsupervised Numerical Reasoning to Extract Phenotypes from Clinical Text by Leveraging External Knowledge

Extracting phenotypes from clinical text has been shown to be useful for a variety of clinical use cases such as identifying patients with rare diseases. However, reasoning with numerical values remains challenging for phenotyping in clinical text, for example, temperature 102F representing Fever. Current state-of-the-art phenotyping models are able to detect general phenotypes, but perform poorly when they detect phenotypes requiring numerical reasoning. We present a novel unsupervised methodology leveraging external knowledge and contextualized word embeddings from ClinicalBERT for numerical reasoning in a variety of phenotypic contexts. Comparing against unsupervised benchmarks, it shows a substantial performance improvement with absolute gains on generalized Recall and F1 scores up to 79% and 71%, respectively. In the supervised setting, it also surpasses the performance of alternative approaches with absolute gains on generalized Recall and F1 scores up to 70% and 44%, respectively.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

Exploiting Multimodal Reinforcement Learning for Simultaneous Machine Translation

This paper addresses the problem of simultaneous machine translation (SiMT) by exploring two main concepts: (a) adaptive policies to learn a good trade-off between high translation quality and low latency; and (b) visual information to support this process by providing additional (visual) contextual information which may be available before the textual input is produced. For that, we propose a multimodal approach to simultaneous machine translation using reinforcement learning, with strategies to integrate visual and textual information in both the agent and the environment. We provide an exploration on how different types of visual information and integration strategies affect the quality and latency of simultaneous translation models, and demonstrate that visual cues lead to higher quality while keeping the latency low.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

Exploring Supervised and Unsupervised Rewards in Machine Translation

Reinforcement Learning (RL) is a powerful framework to address the discrepancy between loss functions used during training and the final evaluation metrics to be used at test time. When applied to neural Machine Translation (MT), it minimises the mismatch between the cross-entropy loss and non-differentiable evaluation metrics like BLEU. However, the suitability of these metrics as reward function at training time is questionable: they tend to be sparse and biased towards the specific words used in the reference texts. We propose to address this problem by making models less reliant on such metrics in two ways: (a) with an entropy-regularised RL method that does not only maximise a reward function but also explore the action space to avoid peaky distributions; (b) with a novel RL method that explores a dynamic unsupervised reward function to balance between exploration and exploitation. We base our proposals on the Soft Actor-Critic (SAC) framework, adapting the off-policy maximum entropy model for language generation applications such as MT. We demonstrate that SAC with BLEU reward tends to overfit less to the training data and performs better on out-of-domain data. We also show that our dynamic unsupervised reward can lead to better translation of ambiguous words.

0 citations0 reviewsNo code linkedOpen access