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Jorge Fernandez-De-Cossio-Diaz

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3 published item(s)

preprint2026arXiv

Spherical Boltzmann machines: a solvable theory of learning and generation in energy-based models

Energy-based models (EBMs) are flexible generative architectures inspired by statistical physics, but their learning and generative properties remain poorly understood. Here, we analyze a solvable EBM in the high-dimensional limit: the spherical Boltzmann machine (SBM). Combining tools from random matrix theory and dynamical mean-field theory, we: solve exact equations describing the training dynamics of the SBM; compute the Bayesian evidence, which acts as a partition function in parameter space and encodes global properties of the trained model; and uncover cascades of phase transitions that occur both during training and as a function of hyperparameters, related to successive alignment and condensation of the top modes of the coupling matrix to the data. We connect these transitions to sampling-time generative phenomena in a teacher-student scenario, including: sampling temperature tuning, double descent as a function of regularization strength, tempered posterior effects, and out-of-equilibrium effects during training that induce biases in the trained model. We provide numerical evidence demonstrating that all these phenomena appear in standard generative architectures, beyond the SBM.

preprint2019arXiv

Spin Glass Theory of Interacting Metabolic Networks

We cast the metabolism of interacting cells within a statistical mechanics framework considering both, the actual phenotypic capacities of each cell and its interaction with its neighbors. Reaction fluxes will be the components of high-dimensional spin vectors, whose values will be constrained by the stochiometry and the energy requirements of the metabolism. Within this picture, finding the phenotypic states of the population turns out to be equivalent to searching for the equilibrium states of a disordered spin model. We provide a general solution of this problem for arbitrary metabolic networks and interactions. We apply this solution to a simplified model of metabolism and to a complex metabolic network, the central core of the \emph{E. coli}, and demonstrate that the combination of selective pressure and interactions define a complex phenotypic space. Cells may specialize in producing or consuming metabolites complementing each other at the population level and this is described by an equilibrium phase space with multiple minima, like in a spin-glass model.

preprint2016arXiv

Fast inference of ill-posed problems within a convex space

In multiple scientific and technological applications we face the problem of having low dimensional data to be justified by a linear model defined in a high dimensional parameter space. The difference in dimensionality makes the problem ill-defined: the model is consistent with the data for many values of its parameters. The objective is to find the probability distribution of parameter values consistent with the data, a problem that can be cast as the exploration of a high dimensional convex polytope. In this work we introduce a novel algorithm to solve this problem efficiently. It provides results that are statistically indistinguishable from currently used numerical techniques while its running time scales linearly with the system size. We show that the algorithm performs robustly in many abstract and practical applications. As working examples we simulate the effects of restricting reaction fluxes on the space of feasible phenotypes of a {\em genome} scale E. Coli metabolic network and infer the traffic flow between origin and destination nodes in a real communication network.