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Jiaxing Huang

Jiaxing Huang contributes to research discovery and scholarly infrastructure.

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Computer Vision Artificial Intelligence Machine Learning Computation and Language math.CA math.CV

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preprint2026arXiv

Bridging Sequence and Graph Structure for Epigenetic Age Prediction

Epigenetic clocks based on DNA methylation have emerged as powerful tools for estimating biological age, with broad applications in aging research, age-related disease studies, and longevity science. Despite advances across machine learning approaches to epigenetic age prediction, spanning penalised linear regression, deep feedforward networks, residual architectures, and graph neural networks, no existing method jointly models co-methylation graph structure and site-specific DNA sequence context within a unified framework. We propose a unified sequence--graph integration framework for epigenetic age prediction that addresses this gap, integrating eight-dimensional DNA sequence statistical features through a lightweight gated modulation mechanism that adaptively scales each site's methylation signal according to its sequence-determined biological relevance prior to graph convolution. Evaluated on 3,707 blood methylation samples against a comprehensive set of baselines, our method achieves a test MAE of 3.149 years, a 12.8\% improvement over the strongest graph-based baseline. Biologically informed statistical features outperform CNN-based sequence encoding, demonstrating that handcrafted sequence features are more effective than end-to-end learned representations in this data regime. Post-hoc interpretability analysis identifies CpG density and local adenine frequency as features with age-dependent importance shifts, consistent with known mechanisms of age-related hypermethylation at CpG-dense promoter regions. Our code is at https://github.com/yaoli2022/graphage-seq.

preprint2026arXiv

Panacea: Mitigating Harmful Fine-tuning for Large Language Models via Post-fine-tuning Perturbation

Harmful fine-tuning attack introduces significant security risks to the fine-tuning services. Main-stream defenses aim to vaccinate the model such that the later harmful fine-tuning attack is less effective. However, our evaluation results show that such defenses are fragile--with a few fine-tuning steps, the model still can learn the harmful knowledge. To this end, we do further experiment and find that an embarrassingly simple solution--adding purely random perturbations to the fine-tuned model, can recover the model from harmful behaviors, though it leads to a degradation in the model's fine-tuning performance. To address the degradation of fine-tuning performance, we further propose Panacea, which optimizes an adaptive perturbation that will be applied to the model after fine-tuning. Panacea maintains model's safety alignment performance without compromising downstream fine-tuning performance. Comprehensive experiments are conducted on different harmful ratios, fine-tuning tasks and mainstream LLMs, where the average harmful scores are reduced by up-to 21.2%, while maintaining fine-tuning performance. As a by-product, we analyze the adaptive perturbation and show that different layers in various LLMs have distinct safety affinity, which coincide with finding from several previous study. Source code available at https://github.com/w-yibo/Panacea.

preprint2026arXiv

PrimeKG-CL: A Continual Graph Learning Benchmark on Evolving Biomedical Knowledge Graphs

Biomedical knowledge graphs underwrite drug repurposing and clinical decision support, yet the upstream ontologies they depend on update on independent cycles that add millions of edges and deprecate hundreds of thousands more between releases. Yet existing continual graph learning has been studied almost exclusively on synthetic random splits of static, generic KGs, a regime that cannot reproduce the asynchronous, structured evolution real biomedical KGs undergo. To this end, we introduce PrimeKG-CL, a CGL benchmark built from nine authoritative biomedical databases (129K+ nodes, 8.1M+ edges, 10 node types, 30 relation types) with two genuine temporal snapshots (June 2021, July 2023; 5.83M edges added, 889K removed, 7.21M persistent), 10 entity-type-grouped tasks, multimodal node features, and a per-task persistent/added/removed test stratification. On three tasks (biomedical relationship prediction, entity classification, KGQA), we evaluate six CL strategies across four KGE decoders, plus LKGE, an LLM-RAG agent, and CMKL. We find that decoder choice and continual learning strategy interact strongly: no single strategy performs best across all decoders, and mismatched combinations can significantly degrade performance. Moreover, only DistMult exhibits a clear separation between persistent and deprecated knowledge, indicating that standard metrics conflate retention of still-valid facts with failure to forget outdated ones; this effect is absent under RotatE. In addition, multimodal features improve entity-level tasks by up to 60%, and a recent CKGE framework (IncDE) failed to scale to our 5.67M-triple base task across five attempts up to 350GB RAM. Data, pipeline, baselines, and the stratified split are released openly. Dataset:huggingface.co/datasets/yradwan147/PrimeKGCL|Code:github.com/yradwan147/primekg-cl-neurips2026

preprint2022arXiv

Category Contrast for Unsupervised Domain Adaptation in Visual Tasks

Instance contrast for unsupervised representation learning has achieved great success in recent years. In this work, we explore the idea of instance contrastive learning in unsupervised domain adaptation (UDA) and propose a novel Category Contrast technique (CaCo) that introduces semantic priors on top of instance discrimination for visual UDA tasks. By considering instance contrastive learning as a dictionary look-up operation, we construct a semantics-aware dictionary with samples from both source and target domains where each target sample is assigned a (pseudo) category label based on the category priors of source samples. This allows category contrastive learning (between target queries and the category-level dictionary) for category-discriminative yet domain-invariant feature representations: samples of the same category (from either source or target domain) are pulled closer while those of different categories are pushed apart simultaneously. Extensive UDA experiments in multiple visual tasks (e.g., segmentation, classification and detection) show that CaCo achieves superior performance as compared with state-of-the-art methods. The experiments also demonstrate that CaCo is complementary to existing UDA methods and generalizable to other learning setups such as unsupervised model adaptation, open-/partial-set adaptation etc.

preprint2022arXiv

Contextual Text Block Detection towards Scene Text Understanding

Most existing scene text detectors focus on detecting characters or words that only capture partial text messages due to missing contextual information. For a better understanding of text in scenes, it is more desired to detect contextual text blocks (CTBs) which consist of one or multiple integral text units (e.g., characters, words, or phrases) in natural reading order and transmit certain complete text messages. This paper presents contextual text detection, a new setup that detects CTBs for better understanding of texts in scenes. We formulate the new setup by a dual detection task which first detects integral text units and then groups them into a CTB. To this end, we design a novel scene text clustering technique that treats integral text units as tokens and groups them (belonging to the same CTB) into an ordered token sequence. In addition, we create two datasets SCUT-CTW-Context and ReCTS-Context to facilitate future research, where each CTB is well annotated by an ordered sequence of integral text units. Further, we introduce three metrics that measure contextual text detection in local accuracy, continuity, and global accuracy. Extensive experiments show that our method accurately detects CTBs which effectively facilitates downstream tasks such as text classification and translation. The project is available at https://sg-vilab.github.io/publication/xue2022contextual/.

preprint2022arXiv

Domain Adaptive Video Segmentation via Temporal Pseudo Supervision

Video semantic segmentation has achieved great progress under the supervision of large amounts of labelled training data. However, domain adaptive video segmentation, which can mitigate data labelling constraints by adapting from a labelled source domain toward an unlabelled target domain, is largely neglected. We design temporal pseudo supervision (TPS), a simple and effective method that explores the idea of consistency training for learning effective representations from unlabelled target videos. Unlike traditional consistency training that builds consistency in spatial space, we explore consistency training in spatiotemporal space by enforcing model consistency across augmented video frames which helps learn from more diverse target data. Specifically, we design cross-frame pseudo labelling to provide pseudo supervision from previous video frames while learning from the augmented current video frames. The cross-frame pseudo labelling encourages the network to produce high-certainty predictions, which facilitates consistency training with cross-frame augmentation effectively. Extensive experiments over multiple public datasets show that TPS is simpler to implement, much more stable to train, and achieves superior video segmentation accuracy as compared with the state-of-the-art.

preprint2022arXiv

MLAN: Multi-Level Adversarial Network for Domain Adaptive Semantic Segmentation

Recent progresses in domain adaptive semantic segmentation demonstrate the effectiveness of adversarial learning (AL) in unsupervised domain adaptation. However, most adversarial learning based methods align source and target distributions at a global image level but neglect the inconsistency around local image regions. This paper presents a novel multi-level adversarial network (MLAN) that aims to address inter-domain inconsistency at both global image level and local region level optimally. MLAN has two novel designs, namely, region-level adversarial learning (RL-AL) and co-regularized adversarial learning (CR-AL). Specifically, RL-AL models prototypical regional context-relations explicitly in the feature space of a labelled source domain and transfers them to an unlabelled target domain via adversarial learning. CR-AL fuses region-level AL and image-level AL optimally via mutual regularization. In addition, we design a multi-level consistency map that can guide domain adaptation in both input space ($i.e.$, image-to-image translation) and output space ($i.e.$, self-training) effectively. Extensive experiments show that MLAN outperforms the state-of-the-art with a large margin consistently across multiple datasets.

preprint2022arXiv

Model Adaptation: Historical Contrastive Learning for Unsupervised Domain Adaptation without Source Data

Unsupervised domain adaptation aims to align a labeled source domain and an unlabeled target domain, but it requires to access the source data which often raises concerns in data privacy, data portability and data transmission efficiency. We study unsupervised model adaptation (UMA), or called Unsupervised Domain Adaptation without Source Data, an alternative setting that aims to adapt source-trained models towards target distributions without accessing source data. To this end, we design an innovative historical contrastive learning (HCL) technique that exploits historical source hypothesis to make up for the absence of source data in UMA. HCL addresses the UMA challenge from two perspectives. First, it introduces historical contrastive instance discrimination (HCID) that learns from target samples by contrasting their embeddings which are generated by the currently adapted model and the historical models. With the historical models, HCID encourages UMA to learn instance-discriminative target representations while preserving the source hypothesis. Second, it introduces historical contrastive category discrimination (HCCD) that pseudo-labels target samples to learn category-discriminative target representations. Specifically, HCCD re-weights pseudo labels according to their prediction consistency across the current and historical models. Extensive experiments show that HCL outperforms and state-of-the-art methods consistently across a variety of visual tasks and setups.

preprint2022arXiv

PolarMix: A General Data Augmentation Technique for LiDAR Point Clouds

LiDAR point clouds, which are usually scanned by rotating LiDAR sensors continuously, capture precise geometry of the surrounding environment and are crucial to many autonomous detection and navigation tasks. Though many 3D deep architectures have been developed, efficient collection and annotation of large amounts of point clouds remain one major challenge in the analytic and understanding of point cloud data. This paper presents PolarMix, a point cloud augmentation technique that is simple and generic but can mitigate the data constraint effectively across different perception tasks and scenarios. PolarMix enriches point cloud distributions and preserves point cloud fidelity via two cross-scan augmentation strategies that cut, edit, and mix point clouds along the scanning direction. The first is scene-level swapping which exchanges point cloud sectors of two LiDAR scans that are cut along the azimuth axis. The second is instance-level rotation and paste which crops point instances from one LiDAR scan, rotates them by multiple angles (to create multiple copies), and paste the rotated point instances into other scans. Extensive experiments show that PolarMix achieves superior performance consistently across different perception tasks and scenarios. In addition, it can work as plug-and-play for various 3D deep architectures and also performs well for unsupervised domain adaptation.

preprint2022arXiv

Spectral Unsupervised Domain Adaptation for Visual Recognition

Though unsupervised domain adaptation (UDA) has achieved very impressive progress recently, it remains a great challenge due to missing target annotations and the rich discrepancy between source and target distributions. We propose Spectral UDA (SUDA), an effective and efficient UDA technique that works in the spectral space and can generalize across different visual recognition tasks. SUDA addresses the UDA challenges from two perspectives. First, it introduces a spectrum transformer (ST) that mitigates inter-domain discrepancies by enhancing domain-invariant spectra while suppressing domain-variant spectra of source and target samples simultaneously. Second, it introduces multi-view spectral learning that learns useful unsupervised representations by maximizing mutual information among multiple ST-generated spectral views of each target sample. Extensive experiments show that SUDA achieves superior accuracy consistently across different visual tasks in object detection, semantic segmentation and image classification. Additionally, SUDA also works with the transformer-based network and achieves state-of-the-art performance on object detection.

preprint2022arXiv

Unbiased Subclass Regularization for Semi-Supervised Semantic Segmentation

Semi-supervised semantic segmentation learns from small amounts of labelled images and large amounts of unlabelled images, which has witnessed impressive progress with the recent advance of deep neural networks. However, it often suffers from severe class-bias problem while exploring the unlabelled images, largely due to the clear pixel-wise class imbalance in the labelled images. This paper presents an unbiased subclass regularization network (USRN) that alleviates the class imbalance issue by learning class-unbiased segmentation from balanced subclass distributions. We build the balanced subclass distributions by clustering pixels of each original class into multiple subclasses of similar sizes, which provide class-balanced pseudo supervision to regularize the class-biased segmentation. In addition, we design an entropy-based gate mechanism to coordinate learning between the original classes and the clustered subclasses which facilitates subclass regularization effectively by suppressing unconfident subclass predictions. Extensive experiments over multiple public benchmarks show that USRN achieves superior performance as compared with the state-of-the-art.

preprint2021arXiv

Cross-View Regularization for Domain Adaptive Panoptic Segmentation

Panoptic segmentation unifies semantic segmentation and instance segmentation which has been attracting increasing attention in recent years. However, most existing research was conducted under a supervised learning setup whereas unsupervised domain adaptive panoptic segmentation which is critical in different tasks and applications is largely neglected. We design a domain adaptive panoptic segmentation network that exploits inter-style consistency and inter-task regularization for optimal domain adaptive panoptic segmentation. The inter-style consistency leverages geometric invariance across the same image of the different styles which fabricates certain self-supervisions to guide the network to learn domain-invariant features. The inter-task regularization exploits the complementary nature of instance segmentation and semantic segmentation and uses it as a constraint for better feature alignment across domains. Extensive experiments over multiple domain adaptive panoptic segmentation tasks (e.g., synthetic-to-real and real-to-real) show that our proposed network achieves superior segmentation performance as compared with the state-of-the-art.

preprint2021arXiv

FSDR: Frequency Space Domain Randomization for Domain Generalization

Domain generalization aims to learn a generalizable model from a known source domain for various unknown target domains. It has been studied widely by domain randomization that transfers source images to different styles in spatial space for learning domain-agnostic features. However, most existing randomization uses GANs that often lack of controls and even alter semantic structures of images undesirably. Inspired by the idea of JPEG that converts spatial images into multiple frequency components (FCs), we propose Frequency Space Domain Randomization (FSDR) that randomizes images in frequency space by keeping domain-invariant FCs (DIFs) and randomizing domain-variant FCs (DVFs) only. FSDR has two unique features: 1) it decomposes images into DIFs and DVFs which allows explicit access and manipulation of them and more controllable randomization; 2) it has minimal effects on semantic structures of images and domain-invariant features. We examined domain variance and invariance property of FCs statistically and designed a network that can identify and fuse DIFs and DVFs dynamically through iterative learning. Extensive experiments over multiple domain generalizable segmentation tasks show that FSDR achieves superior segmentation and its performance is even on par with domain adaptation methods that access target data in training.

preprint2020arXiv

Contextual-Relation Consistent Domain Adaptation for Semantic Segmentation

Recent advances in unsupervised domain adaptation for semantic segmentation have shown great potentials to relieve the demand of expensive per-pixel annotations. However, most existing works address the domain discrepancy by aligning the data distributions of two domains at a global image level whereas the local consistencies are largely neglected. This paper presents an innovative local contextual-relation consistent domain adaptation (CrCDA) technique that aims to achieve local-level consistencies during the global-level alignment. The idea is to take a closer look at region-wise feature representations and align them for local-level consistencies. Specifically, CrCDA learns and enforces the prototypical local contextual-relations explicitly in the feature space of a labelled source domain while transferring them to an unlabelled target domain via backpropagation-based adversarial learning. An adaptive entropy max-min adversarial learning scheme is designed to optimally align these hundreds of local contextual-relations across domain without requiring discriminator or extra computation overhead. The proposed CrCDA has been evaluated extensively over two challenging domain adaptive segmentation tasks (e.g., GTA5 to Cityscapes and SYNTHIA to Cityscapes), and experiments demonstrate its superior segmentation performance as compared with state-of-the-art methods.

preprint2020arXiv

Hypertranscendency of Perturbations of Hypertranscendental Functions

Inspired by the work of Bank on the hypertranscendence of $Γe^h$ where $Γ$ is the Euler gamma function and $h$ is an entire function, we investigate when a meromorphic function $fe^g$ cannot satisfy any algebraic differential equation over certain field of meromorphic functions, where $f$ and $g$ are meromorphic and entire on the complex plane, respectively. Our results (Theorem 1 and 2) give partial solutions to Bank's Conjecture (1977) on the hypertranscendence of $Γe^h$. We also give some sufficient conditions for hypertranscendence of meromorphic function of the form $f+g$, $f\cdot g$ and $f\circ g$ in Theorem 3 and 4.

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