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Jiaxin Qi

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Published work

3 published item(s)

preprint2026arXiv

Intrinsic Gradient Suppression for Label-Noise Prompt Tuning in Vision-Language Models

Contrastive vision-language models like CLIP exhibit remarkable zero-shot generalization. However, prompt tuning remains highly sensitive to label noise, as mislabeled samples generate disproportionately large gradients that can overwhelm pre-trained priors. We argue that because CLIP already provides a near-optimal initialization, adaptation should be inherently conservative, particularly against the extreme gradient updates common in noisy settings. To this end, we propose Double-Softmax Prompt Tuning (DSPT), a hyperparameter-free method for intrinsic gradient suppression. By applying a sequential probabilistic normalization, DSPT induces a self-adaptive saturation zone that suppresses gradients from high-error noisy samples while maintaining informative updates. We also provide both theoretical analysis and empirical evidence about how this mechanism achieves adaptive suppression. This design transforms ``gradient vanishing'', traditionally a training bottleneck, into a principled noise-filtering shield for label-noise prompt tuning. Extensive experiments confirm that this simple, drop-in design achieves state-of-the-art robustness across various noisy benchmarks, outperforming methods with complex architectures and handcrafted hyperparameters.

preprint2026arXiv

Towards Universal Gene Regulatory Network Inference: Unlocking Generalizable Regulatory Knowledge in Single-cell Foundation Models

Gene Regulatory Network (GRN) inference is essential for understanding complex cellular mechanisms, rendered tractable through single-cell transcriptomic data. With the emergence of single-cell Foundation Models (scFMs), enhanced transcriptomic encoding is widely expected to revolutionize GRN inference. However, we observe that their performance remains far from satisfactory. The primary reason is that the standard reconstruction-based pre-training objectives often fail to explicitly capture latent regulatory signals. To bridge this gap, we first introduce a GRN generalization benchmark designed to evaluate regulatory predictions on unseen genes and datasets, which relies on the zero-shot capabilities of scFMs and is inherently challenging for traditional methods. Furthermore, to unlock the regulatory knowledge within the foundation models, we propose two novel methods, Virtual Value Perturbation and Gradient Trajectory, to distill implicit regulatory information from scFMs into highly generalizable inter-gene features. Extensive experiments demonstrate that our approach significantly outperforms existing methods, establishing a new paradigm for leveraging the potential of scFMs in universal GRN inference.

preprint2021arXiv

Deconfounded Visual Grounding

We focus on the confounding bias between language and location in the visual grounding pipeline, where we find that the bias is the major visual reasoning bottleneck. For example, the grounding process is usually a trivial language-location association without visual reasoning, e.g., grounding any language query containing sheep to the nearly central regions, due to that most queries about sheep have ground-truth locations at the image center. First, we frame the visual grounding pipeline into a causal graph, which shows the causalities among image, query, target location and underlying confounder. Through the causal graph, we know how to break the grounding bottleneck: deconfounded visual grounding. Second, to tackle the challenge that the confounder is unobserved in general, we propose a confounder-agnostic approach called: Referring Expression Deconfounder (RED), to remove the confounding bias. Third, we implement RED as a simple language attention, which can be applied in any grounding method. On popular benchmarks, RED improves various state-of-the-art grounding methods by a significant margin. Code will soon be available at: https://github.com/JianqiangH/Deconfounded_VG.