Researcher profile

Hector Gomez

Hector Gomez contributes to research discovery and scholarly infrastructure.

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Published work

5 published item(s)

preprint2026arXiv

AeroJEPA: Learning Semantic Latent Representations for Scalable 3D Aerodynamic Field Modeling

Aerodynamic surrogate models are increasingly used to replace repeated high-fidelity CFD evaluations in many-query design settings, but current approaches still face two important limitations: they often scale poorly to the very large fields arising in realistic 3D aerodynamics, and they rarely produce latent representations that are directly useful for analysis and design. We introduce AeroJEPA, a Joint-Embedding Predictive Architecture for aerodynamic field modeling that addresses both issues. Rather than predicting the full flow field directly from geometry, AeroJEPA predicts a target latent representation of the flow from a context latent representation of the geometry and operating conditions, and optionally reconstructs the field through a continuous implicit decoder. This formulation decouples latent prediction from field resolution while encouraging the latent space to organize semantically. We evaluate AeroJEPA on two complementary datasets: HiLiftAeroML, which stresses the method in a high-fidelity regime with extremely large boundary-layer fields, and SuperWing, which tests large-scale generalization and latent-space optimization over a broad family of transonic wings. Across these benchmarks, AeroJEPA is competitive as a continuous surrogate for aerodynamic fields, scales naturally to high-resolution outputs, and learns context and predicted latents that encode geometry and aerodynamic quantities not used directly as supervision. We further show that the resulting latent space supports controlled interpolation, linear probing, concept-vector arithmetic, and a constrained design latent-optimization experiment. These results suggest that predictive latent learning is a promising direction for scalable and design-meaningful aerodynamic surrogate modeling.

preprint2026arXiv

Effect of Electric Charge on Biotherapeutic Transport, Binding and Absorption: A Computational Study

This study explores the effects of electric charge on the dynamics of drug transport and absorption in subcutaneous injections of monoclonal antibodies (mAbs). We develop a novel mathematical and computational model, based on the Nernst-Planck equations and porous media flow theory, to investigate the complex interactions between mAbs and charged species in subcutaneous tissue. The model enables us to study short-term transport dynamics and long-term binding and absorption for two mAbs with different electric properties. We examine the influence of buffer pH, body mass index, injection depth, and formulation concentration on drug distribution and compare our numerical results with experimental data from the literature.

preprint2021arXiv

A Petrov-Galerkin method for nonlocal convection-dominated diffusion problems

We present a Petrov-Gelerkin (PG) method for a class of nonlocal convection-dominated diffusion problems. There are two main ingredients in our approach. First, we define the norm on the test space as induced by the trial space norm, i.e., the optimal test norm, so that the inf-sup condition can be satisfied uniformly independent of the problem. We show the well-posedness of a class of nonlocal convection-dominated diffusion problems under the optimal test norm with general assumptions on the nonlocal diffusion and convection kernels. Second, following the framework of Cohen et al.~(2012), we embed the original nonlocal convection-dominated diffusion problem into a larger mixed problem so as to choose an enriched test space as a stabilization of the numerical algorithm. In the numerical experiments, we use an approximate optimal test norm which can be efficiently implemented in 1d, and study its performance against the energy norm on the test space. We conduct convergence studies for the nonlocal problem using uniform $h$- and $p$-refinements, and adaptive $h$-refinements on both smooth manufactured solutions and solutions with sharp gradient in a transition layer. In addition, we confirm that the PG method is asymptotically compatible.

preprint2020arXiv

A deep learning framework for solution and discovery in solid mechanics

We present the application of a class of deep learning, known as Physics Informed Neural Networks (PINN), to learning and discovery in solid mechanics. We explain how to incorporate the momentum balance and constitutive relations into PINN, and explore in detail the application to linear elasticity, and illustrate its extension to nonlinear problems through an example that showcases von~Mises elastoplasticity. While common PINN algorithms are based on training one deep neural network (DNN), we propose a multi-network model that results in more accurate representation of the field variables. To validate the model, we test the framework on synthetic data generated from analytical and numerical reference solutions. We study convergence of the PINN model, and show that Isogeometric Analysis (IGA) results in superior accuracy and convergence characteristics compared with classic low-order Finite Element Method (FEM). We also show the applicability of the framework for transfer learning, and find vastly accelerated convergence during network re-training. Finally, we find that honoring the physics leads to improved robustness: when trained only on a few parameters, we find that the PINN model can accurately predict the solution for a wide range of parameters new to the network---thus pointing to an important application of this framework to sensitivity analysis and surrogate modeling.

preprint2020arXiv

Optimal control of cytotoxic and antiangiogenic therapies on prostate cancer growth

Prostate cancer can be lethal in advanced stages, for which chemotherapy may become the only viable therapeutic option. While there is no clear clinical management strategy fitting all patients, cytotoxic chemotherapy with docetaxel is currently regarded as the gold standard. However, tumors may regain activity after treatment conclusion and become resistant to docetaxel. This situation calls for new delivery strategies and drug compounds enabling an improved therapeutic outcome. Combination of docetaxel with antiangiogenic therapy has been considered a promising strategy. Bevacizumab is the most common antiangiogenic drug, but clinical studies have not revealed a clear benefit from its combination with docetaxel. Here, we capitalize on our prior work on mathematical modeling of prostate cancer growth subjected to combined cytotoxic and antiangiogenic therapies, and propose an optimal control framework to robustly compute the drug-independent cytotoxic and antiangiogenic effects enabling an optimal therapeutic control of tumor dynamics. We describe the formulation of the optimal control problem, for which we prove the existence of at least a solution and determine the necessary first order optimality conditions. We then present numerical algorithms based on isogeometric analysis to run a preliminary simulation study over a single cycle of combined therapy. Our results suggest that only cytotoxic chemotherapy is required to optimize therapeutic performance and we show that our framework can produce superior solutions to combined therapy with docetaxel and bevacizumab. We also illustrate how the optimal drug-naïve cytotoxic effects computed in these simulations may be successfully leveraged to guide drug production and delivery strategies by running a nonlinear least-square fit of protocols involving docetaxel and a new design drug.