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Hau-San Wong

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3 published item(s)

preprint2026arXiv

Post-Training as Reweighting: A Stochastic View of Reasoning Trajectories in Language Models

Foundation models encode rich structural knowledge but often rely on post-training procedures to adapt their reasoning behavior to specific tasks. Popular approaches such as reinforcement learning with verifiable rewards (RLVR) and inference-time reward aggregation are typically analyzed from a performance perspective, leaving their effects on the underlying reasoning distribution less understood. In this work, we study post-training reasoning from a stochastic trajectory viewpoint. Following Kim et al. (2025), we model reasoning steps of varying difficulty as Markov transitions with different probabilities, and formalize reasoning processes using tree-structured Markov chains. Within this framework, pretraining corresponds to discovering the reasoning structure, while post-training primarily reweights existing chains of thought. We show that both RLVR and inference-time reward aggregation concentrate probability mass on a small number of high-probability trajectories, leading to the suppression of rare but essential reasoning paths. As a consequence, solving hard instances often depends on low-probability trajectories already present in the base model. We further prove that exploration-oriented mechanisms, such as rejecting easy instances and applying KL regularization, help preserve these rare trajectories. Empirical simulations support our theoretical analysis.

preprint2026arXiv

Reasoning Before Diagnosis: Physician-Inspired Structured Thinking for ECG Classification

Electrocardiogram (ECG) diagnosis in clinical practice relies on structured reasoning over multiple hierarchical aspects, including cardiac rhythm, conduction properties, waveform morphology, and overall diagnostic impression. However, most existing approaches predict labels directly from ECG signals without explicit clinical reasoning, resulting in opaque decisions that lack clinical alignment. To bridge this gap, we propose CardioThink, a physician-inspired multimodal large language model (MLLM) framework that explicitly models the diagnostic reasoning process through human-interpretable intermediate stages (rhythm, conduction, morphology, and impression) to derive final classification results. Furthermore, we introduce Structured Set Policy Optimization (SSPO) to jointly optimize adherence to this structured reasoning format and the accuracy of variable-size diagnostic sets, without requiring manually annotated reasoning traces. Extensive experiments on diverse ECG benchmarks demonstrate the significant superiority of our approach in diagnostic accuracy, while simultaneously providing interpretable clinical reasoning. Notably, reasoning quality evaluations confirm that SSPO substantially enhances the clinical validity of the generated rationales. These findings reveal that moving beyond direct label prediction toward structured reasoning offers a more clinically aligned direction for future ECG modeling.

preprint2012arXiv

Towards a Mathematical Foundation of Immunology and Amino Acid Chains

We attempt to set a mathematical foundation of immunology and amino acid chains. To measure the similarities of these chains, a kernel on strings is defined using only the sequence of the chains and a good amino acid substitution matrix (e.g. BLOSUM62). The kernel is used in learning machines to predict binding affinities of peptides to human leukocyte antigens DR (HLA-DR) molecules. On both fixed allele (Nielsen and Lund 2009) and pan-allele (Nielsen et.al. 2010) benchmark databases, our algorithm achieves the state-of-the-art performance. The kernel is also used to define a distance on an HLA-DR allele set based on which a clustering analysis precisely recovers the serotype classifications assigned by WHO (Nielsen and Lund 2009, and Marsh et.al. 2010). These results suggest that our kernel relates well the chain structure of both peptides and HLA-DR molecules to their biological functions, and that it offers a simple, powerful and promising methodology to immunology and amino acid chain studies.