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Researcher profile

Chenyu You

Chenyu You contributes to research discovery and scholarly infrastructure.

ResearcherAffiliation not importedOpen to collaborate
Machine LearningArtificial IntelligenceComputer VisionComputation and Languageeess.IVeess.ASSound

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Published work

19 published item(s)

preprint2026arXiv

CHI-Bench: Can AI Agents Automate End-to-End, Long-Horizon, Policy-Rich Healthcare Workflows?

End-to-end automation of realistic healthcare operations stresses three capabilities underrepresented in current benchmarks: policy density, decisions must be grounded in a large library of medical, insurance, and operational rules; Multi-role composition: a single task requires the agent to play multiple roles with handoffs; and multilateral interaction: intermediate workflow steps are multi-turn dialogs, such as peer-to-peer review and patient outreach. We introduce $χ$-Bench, a benchmark of long-horizon healthcare workflows across three domains: provider prior authorization, payer utilization management, and care management. Each task hands the agent a clinical case in a high-fidelity simulator of 20 healthcare apps exposed via 87 MCP tools, which it must drive to a terminal status through tool calls and writing the role's artifacts, guided by a 1,290+ document managed-care operations handbook skill. Across 30 agent harness/models configurations, the best agent resolves only 28.0% of tasks, no agent clears 20% on strict pass^3, and executing all tasks in a single session slumps the performance to 3.8%. These results raise the hypothesis that similar gaps are likely to surface in other policy-dense, role-composed, irreversible enterprise domains.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

FORESTLLM: Large Language Models Make Random Forest Great on Few-shot Tabular Learning

Tabular data high-stakes critical decision-making in domains such as finance, healthcare, and scientific discovery. Yet, learning effectively from tabular data in few-shot settings, where labeled examples are scarce, remains a fundamental challenge. Traditional tree-based methods often falter in these regimes due to their reliance on statistical purity metrics, which become unstable and prone to overfitting with limited supervision. At the same time, direct applications of large language models (LLMs) often overlook its inherent structure, leading to suboptimal performance. To overcome these limitations, we propose FORESTLLM, a novel framework that unifies the structural inductive biases of decision forests with the semantic reasoning capabilities of LLMs. Crucially, FORESTLLM leverages the LLM only during training, treating it as an offline model designer that encodes rich, contextual knowledge into a lightweight, interpretable forest model, eliminating the need for LLM inference at test time. Our method is two-fold. First, we introduce a semantic splitting criterion in which the LLM evaluates candidate partitions based on their coherence over both labeled and unlabeled data, enabling the induction of more robust and generalizable tree structures under few-shot supervision. Second, we propose a one-time in-context inference mechanism for leaf node stabilization, where the LLM distills the decision path and its supporting examples into a concise, deterministic prediction, replacing noisy empirical estimates with semantically informed outputs. Across a diverse suite of few-shot classification and regression benchmarks, FORESTLLM achieves state-of-the-art performance.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

Geometric and Dynamic Scaling in Deep Transformers

Despite their empirical success, pushing Transformer architectures to extreme depth often leads to a paradoxical failure: representations become increasingly redundant, lose rank, and ultimately collapse. Existing explanations largely attribute this phenomenon to optimization instability or vanishing gradients, yet such accounts fail to explain why collapse persists even under modern normalization and initialization schemes. In this paper, we argue that the collapse of deep Transformers is fundamentally a geometric problem. Standard residual updates implicitly assume that feature accumulation is always beneficial, but offer no mechanism to constrain update directions or to erase outdated information. As depth increases, this leads to systematic drift off the semantic manifold and monotonic feature accumulation, causing representational degeneracy. We propose a unified geometric framework that addresses these failures through two orthogonal principles. First, manifold-constrained hyper-connections restrict residual updates to valid local tangent directions, preventing uncontrolled manifold drift. Second, deep delta learning introduces data-dependent, non-monotonic updates that enable reflection and erasure of redundant features rather than their unconditional accumulation. Together, these mechanisms decouple the direction and sign of feature updates, yielding a stable geometric evolution across depth. We term the resulting architecture the Manifold-Geometric Transformer (MGT). Our analysis predicts that enforcing geometric validity while allowing dynamic erasure is essential for avoiding rank collapse in ultra-deep networks. We outline an evaluation protocol for Transformers exceeding 100 layers to test the hypothesis that geometry, rather than depth itself, is the key limiting factor in deep representation learning.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

PROMISE-AD: Progression-aware Multi-horizon Survival Estimation for Alzheimer's Disease Progression and Dynamic Tracking

Individualized Alzheimer's disease (AD) progression prediction requires models that use irregular visits, account for censoring, avoid diagnostic leakage, and provide calibrated horizon risks. We propose PROgression-aware MultI-horizon Survival Estimation for Alzheimer's Disease (PROMISE-AD), a leakage-safe survival framework for predicting conversion from cognitively normal (CN) to mild cognitive impairment (MCI) and from MCI to AD dementia using ADNI/TADPOLE tabular histories. PROMISE-AD converts pre-index visits into tokens with standardized measurements, missingness masks, longitudinal changes, time-normalized slopes, visit timing, and non-diagnostic categorical attributes. A temporal Transformer fuses global, attention-pooled, and latest-visit representations to estimate a progression score and latent discrete-time mixture hazards. Training combines survival likelihood, horizon-specific focal risk loss, progression ranking, hazard smoothness, and mixture-balance regularization, followed by validation-set isotonic calibration for 1-, 2-, 3-, and 5-year risks. In held-out testing across three seeds, PROMISE-AD achieved an integrated Brier score (IBS) of 0.085 $\pm$ 0.012, C-index of 0.808 $\pm$ 0.015, and mean time-dependent AUC of 0.840 $\pm$ 0.081 for CN-to-MCI conversion, yielding the lowest IBS among compared methods. For MCI-to-AD conversion, PROMISE-AD achieved the highest C-index (0.894 $\pm$ 0.018) and near-ceiling 5-year discrimination (AUROC 0.997 $\pm$ 0.003; AUPRC 0.999 $\pm$ 0.001), although some baselines had lower IBS. Ablations and interpretability supported longitudinal change features, fused temporal representations, mixture hazards, cognitive and functional measures, APOE4 status, and recent conversion-proximal visits. These findings suggest that progression-aware survival modeling can provide interpretable multi-horizon AD conversion risk estimates.

0 citations0 reviewsNo code linkedOpen access
preprint2026arXiv

When to Think, When to Speak: Learning Disclosure Policies for LLM Reasoning

In single-stream autoregressive interfaces, the same tokens both update the model state and constitute an irreversible public commitment. This coupling creates a silence tax: additional deliberation postpones the first task-relevant content, while naive early streaming risks premature commitments that bias subsequent generations. We introduce Side-by-Side (SxS) Interleaved Reasoning, which makes disclosure timing a controllable decision within standard autoregressive generation. SxS interleaves partial disclosures with continued private reasoning in the same context, but releases content only when it is supported by the reasoning so far. To learn such pacing without incentivizing filler, we construct entailment-aligned interleaved trajectories by matching answer prefixes to supporting reasoning prefixes, then train with SFT to acquire the dual-action semantics and RL to recover reasoning performance under the new format. Across two Qwen3 architectures/scales (MoE Qwen3-30B-A3B, dense Qwen3-4B) and both in-domain (AIME25) and out-of-domain (GPQA-Diamond) benchmarks, SxS improves accuracy--content-latency Pareto trade-offs under token-level proxies such as inter-update waiting.

0 citations0 reviewsNo code linkedOpen access
preprint2024arXiv

Backdoor Attack on Unpaired Medical Image-Text Foundation Models: A Pilot Study on MedCLIP

In recent years, foundation models (FMs) have solidified their role as cornerstone advancements in the deep learning domain. By extracting intricate patterns from vast datasets, these models consistently achieve state-of-the-art results across a spectrum of downstream tasks, all without necessitating extensive computational resources. Notably, MedCLIP, a vision-language contrastive learning-based medical FM, has been designed using unpaired image-text training. While the medical domain has often adopted unpaired training to amplify data, the exploration of potential security concerns linked to this approach hasn't kept pace with its practical usage. Notably, the augmentation capabilities inherent in unpaired training also indicate that minor label discrepancies can result in significant model deviations. In this study, we frame this label discrepancy as a backdoor attack problem. We further analyze its impact on medical FMs throughout the FM supply chain. Our evaluation primarily revolves around MedCLIP, emblematic of medical FM employing the unpaired strategy. We begin with an exploration of vulnerabilities in MedCLIP stemming from unpaired image-text matching, termed BadMatch. BadMatch is achieved using a modest set of wrongly labeled data. Subsequently, we disrupt MedCLIP's contrastive learning through BadDist-assisted BadMatch by introducing a Bad-Distance between the embeddings of clean and poisoned data. Additionally, combined with BadMatch and BadDist, the attacking pipeline consistently fends off backdoor assaults across diverse model designs, datasets, and triggers. Also, our findings reveal that current defense strategies are insufficient in detecting these latent threats in medical FMs' supply chains.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

End-to-end Spoken Conversational Question Answering: Task, Dataset and Model

In spoken question answering, the systems are designed to answer questions from contiguous text spans within the related speech transcripts. However, the most natural way that human seek or test their knowledge is via human conversations. Therefore, we propose a new Spoken Conversational Question Answering task (SCQA), aiming at enabling the systems to model complex dialogue flows given the speech documents. In this task, our main objective is to build the system to deal with conversational questions based on the audio recordings, and to explore the plausibility of providing more cues from different modalities with systems in information gathering. To this end, instead of directly adopting automatically generated speech transcripts with highly noisy data, we propose a novel unified data distillation approach, DDNet, which effectively ingests cross-modal information to achieve fine-grained representations of the speech and language modalities. Moreover, we propose a simple and novel mechanism, termed Dual Attention, by encouraging better alignments between audio and text to ease the process of knowledge transfer. To evaluate the capacity of SCQA systems in a dialogue-style interaction, we assemble a Spoken Conversational Question Answering (Spoken-CoQA) dataset with more than 40k question-answer pairs from 4k conversations. The performance of the existing state-of-the-art methods significantly degrade on our dataset, hence demonstrating the necessity of cross-modal information integration. Our experimental results demonstrate that our proposed method achieves superior performance in spoken conversational question answering tasks.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Exploring and Exploiting Multi-Granularity Representations for Machine Reading Comprehension

Recently, the attention-enhanced multi-layer encoder, such as Transformer, has been extensively studied in Machine Reading Comprehension (MRC). To predict the answer, it is common practice to employ a predictor to draw information only from the final encoder layer which generates the coarse-grained representations of the source sequences, i.e., passage and question. The analysis shows that the representation of source sequence becomes more coarse-grained from finegrained as the encoding layer increases. It is generally believed that with the growing number of layers in deep neural networks, the encoding process will gather relevant information for each location increasingly, resulting in more coarse-grained representations, which adds the likelihood of similarity to other locations (referring to homogeneity). Such phenomenon will mislead the model to make wrong judgement and degrade the performance. In this paper, we argue that it would be better if the predictor could exploit representations of different granularity from the encoder, providing different views of the source sequences, such that the expressive power of the model could be fully utilized. To this end, we propose a novel approach called Adaptive Bidirectional Attention-Capsule Network (ABA-Net), which adaptively exploits the source representations of different levels to the predictor. Furthermore, due to the better representations are at the core for boosting MRC performance, the capsule network and self-attention module are carefully designed as the building blocks of our encoders, which provides the capability to explore the local and global representations, respectively. Experimental results on three benchmark datasets, i.e., SQuAD 1.0, SQuAD 2.0 and COQA, demonstrate the effectiveness of our approach. In particular, we set the new state-of-the-art performance on the SQuAD 1.0 dataset

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Flow-based Visual Quality Enhancer for Super-resolution Magnetic Resonance Spectroscopic Imaging

Magnetic Resonance Spectroscopic Imaging (MRSI) is an essential tool for quantifying metabolites in the body, but the low spatial resolution limits its clinical applications. Deep learning-based super-resolution methods provided promising results for improving the spatial resolution of MRSI, but the super-resolved images are often blurry compared to the experimentally-acquired high-resolution images. Attempts have been made with the generative adversarial networks to improve the image visual quality. In this work, we consider another type of generative model, the flow-based model, of which the training is more stable and interpretable compared to the adversarial networks. Specifically, we propose a flow-based enhancer network to improve the visual quality of super-resolution MRSI. Different from previous flow-based models, our enhancer network incorporates anatomical information from additional image modalities (MRI) and uses a learnable base distribution. In addition, we impose a guide loss and a data-consistency loss to encourage the network to generate images with high visual quality while maintaining high fidelity. Experiments on a 1H-MRSI dataset acquired from 25 high-grade glioma patients indicate that our enhancer network outperforms the adversarial networks and the baseline flow-based methods. Our method also allows visual quality adjustment and uncertainty estimation.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Graph-in-Graph Network for Automatic Gene Ontology Description Generation

Gene Ontology (GO) is the primary gene function knowledge base that enables computational tasks in biomedicine. The basic element of GO is a term, which includes a set of genes with the same function. Existing research efforts of GO mainly focus on predicting gene term associations. Other tasks, such as generating descriptions of new terms, are rarely pursued. In this paper, we propose a novel task: GO term description generation. This task aims to automatically generate a sentence that describes the function of a GO term belonging to one of the three categories, i.e., molecular function, biological process, and cellular component. To address this task, we propose a Graph-in-Graph network that can efficiently leverage the structural information of GO. The proposed network introduces a two-layer graph: the first layer is a graph of GO terms where each node is also a graph (gene graph). Such a Graph-in-Graph network can derive the biological functions of GO terms and generate proper descriptions. To validate the effectiveness of the proposed network, we build three large-scale benchmark datasets. By incorporating the proposed Graph-in-Graph network, the performances of seven different sequence-to-sequence models can be substantially boosted across all evaluation metrics, with up to 34.7%, 14.5%, and 39.1% relative improvements in BLEU, ROUGE-L, and METEOR, respectively.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Incremental Learning Meets Transfer Learning: Application to Multi-site Prostate MRI Segmentation

Many medical datasets have recently been created for medical image segmentation tasks, and it is natural to question whether we can use them to sequentially train a single model that (1) performs better on all these datasets, and (2) generalizes well and transfers better to the unknown target site domain. Prior works have achieved this goal by jointly training one model on multi-site datasets, which achieve competitive performance on average but such methods rely on the assumption about the availability of all training data, thus limiting its effectiveness in practical deployment. In this paper, we propose a novel multi-site segmentation framework called incremental-transfer learning (ITL), which learns a model from multi-site datasets in an end-to-end sequential fashion. Specifically, "incremental" refers to training sequentially constructed datasets, and "transfer" is achieved by leveraging useful information from the linear combination of embedding features on each dataset. In addition, we introduce our ITL framework, where we train the network including a site-agnostic encoder with pre-trained weights and at most two segmentation decoder heads. We also design a novel site-level incremental loss in order to generalize well on the target domain. Second, we show for the first time that leveraging our ITL training scheme is able to alleviate challenging catastrophic forgetting problems in incremental learning. We conduct experiments using five challenging benchmark datasets to validate the effectiveness of our incremental-transfer learning approach. Our approach makes minimal assumptions on computation resources and domain-specific expertise, and hence constitutes a strong starting point in multi-site medical image segmentation.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

KerGNNs: Interpretable Graph Neural Networks with Graph Kernels

Graph kernels are historically the most widely-used technique for graph classification tasks. However, these methods suffer from limited performance because of the hand-crafted combinatorial features of graphs. In recent years, graph neural networks (GNNs) have become the state-of-the-art method in downstream graph-related tasks due to their superior performance. Most GNNs are based on Message Passing Neural Network (MPNN) frameworks. However, recent studies show that MPNNs can not exceed the power of the Weisfeiler-Lehman (WL) algorithm in graph isomorphism test. To address the limitations of existing graph kernel and GNN methods, in this paper, we propose a novel GNN framework, termed \textit{Kernel Graph Neural Networks} (KerGNNs), which integrates graph kernels into the message passing process of GNNs. Inspired by convolution filters in convolutional neural networks (CNNs), KerGNNs adopt trainable hidden graphs as graph filters which are combined with subgraphs to update node embeddings using graph kernels. In addition, we show that MPNNs can be viewed as special cases of KerGNNs. We apply KerGNNs to multiple graph-related tasks and use cross-validation to make fair comparisons with benchmarks. We show that our method achieves competitive performance compared with existing state-of-the-art methods, demonstrating the potential to increase the representation ability of GNNs. We also show that the trained graph filters in KerGNNs can reveal the local graph structures of the dataset, which significantly improves the model interpretability compared with conventional GNN models.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Learning correspondences of cardiac motion from images using biomechanics-informed modeling

Learning spatial-temporal correspondences in cardiac motion from images is important for understanding the underlying dynamics of cardiac anatomical structures. Many methods explicitly impose smoothness constraints such as the $\mathcal{L}_2$ norm on the displacement vector field (DVF), while usually ignoring biomechanical feasibility in the transformation. Other geometric constraints either regularize specific regions of interest such as imposing incompressibility on the myocardium or introduce additional steps such as training a separate network-based regularizer on physically simulated datasets. In this work, we propose an explicit biomechanics-informed prior as regularization on the predicted DVF in modeling a more generic biomechanically plausible transformation within all cardiac structures without introducing additional training complexity. We validate our methods on two publicly available datasets in the context of 2D MRI data and perform extensive experiments to illustrate the effectiveness and robustness of our proposed methods compared to other competing regularization schemes. Our proposed methods better preserve biomechanical properties by visual assessment and show advantages in segmentation performance using quantitative evaluation metrics. The code is publicly available at \url{https://github.com/Voldemort108X/bioinformed_reg}.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Momentum Contrastive Voxel-wise Representation Learning for Semi-supervised Volumetric Medical Image Segmentation

Contrastive learning (CL) aims to learn useful representation without relying on expert annotations in the context of medical image segmentation. Existing approaches mainly contrast a single positive vector (i.e., an augmentation of the same image) against a set of negatives within the entire remainder of the batch by simply mapping all input features into the same constant vector. Despite the impressive empirical performance, those methods have the following shortcomings: (1) it remains a formidable challenge to prevent the collapsing problems to trivial solutions; and (2) we argue that not all voxels within the same image are equally positive since there exist the dissimilar anatomical structures with the same image. In this work, we present a novel Contrastive Voxel-wise Representation Learning (CVRL) method to effectively learn low-level and high-level features by capturing 3D spatial context and rich anatomical information along both the feature and the batch dimensions. Specifically, we first introduce a novel CL strategy to ensure feature diversity promotion among the 3D representation dimensions. We train the framework through bi-level contrastive optimization (i.e., low-level and high-level) on 3D images. Experiments on two benchmark datasets and different labeled settings demonstrate the superiority of our proposed framework. More importantly, we also prove that our method inherits the benefit of hardness-aware property from the standard CL approaches.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Multi-scale Super-resolution Magnetic Resonance Spectroscopic Imaging with Adjustable Sharpness

Magnetic Resonance Spectroscopic Imaging (MRSI) is a valuable tool for studying metabolic activities in the human body, but the current applications are limited to low spatial resolutions. The existing deep learning-based MRSI super-resolution methods require training a separate network for each upscaling factor, which is time-consuming and memory inefficient. We tackle this multi-scale super-resolution problem using a Filter Scaling strategy that modulates the convolution filters based on the upscaling factor, such that a single network can be used for various upscaling factors. Observing that each metabolite has distinct spatial characteristics, we also modulate the network based on the specific metabolite. Furthermore, our network is conditioned on the weight of adversarial loss so that the perceptual sharpness of the super-resolved metabolic maps can be adjusted within a single network. We incorporate these network conditionings using a novel Multi-Conditional Module. The experiments were carried out on a 1H-MRSI dataset from 15 high-grade glioma patients. Results indicate that the proposed network achieves the best performance among several multi-scale super-resolution methods and can provide super-resolved metabolic maps with adjustable sharpness.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

Rethinking and Improving Natural Language Generation with Layer-Wise Multi-View Decoding

In sequence-to-sequence learning, e.g., natural language generation, the decoder relies on the attention mechanism to efficiently extract information from the encoder. While it is common practice to draw information from only the last encoder layer, recent work has proposed to use representations from different encoder layers for diversified levels of information. Nonetheless, the decoder still obtains only a single view of the source sequences, which might lead to insufficient training of the encoder layer stack due to the hierarchy bypassing problem. In this work, we propose layer-wise multi-view decoding, where for each decoder layer, together with the representations from the last encoder layer, which serve as a global view, those from other encoder layers are supplemented for a stereoscopic view of the source sequences. Systematic experiments and analyses show that we successfully address the hierarchy bypassing problem, require almost negligible parameter increase, and substantially improve the performance of sequence-to-sequence learning with deep representations on five diverse tasks, i.e., machine translation, abstractive summarization, image captioning, video captioning, medical report generation, and paraphrase generation. In particular, our approach achieves new state-of-the-art results on ten benchmark datasets, including a low-resource machine translation dataset and two low-resource medical report generation datasets.

0 citations0 reviewsNo code linkedOpen access
preprint2022arXiv

SimCVD: Simple Contrastive Voxel-Wise Representation Distillation for Semi-Supervised Medical Image Segmentation

Automated segmentation in medical image analysis is a challenging task that requires a large amount of manually labeled data. However, most existing learning-based approaches usually suffer from limited manually annotated medical data, which poses a major practical problem for accurate and robust medical image segmentation. In addition, most existing semi-supervised approaches are usually not robust compared with the supervised counterparts, and also lack explicit modeling of geometric structure and semantic information, both of which limit the segmentation accuracy. In this work, we present SimCVD, a simple contrastive distillation framework that significantly advances state-of-the-art voxel-wise representation learning. We first describe an unsupervised training strategy, which takes two views of an input volume and predicts their signed distance maps of object boundaries in a contrastive objective, with only two independent dropout as mask. This simple approach works surprisingly well, performing on the same level as previous fully supervised methods with much less labeled data. We hypothesize that dropout can be viewed as a minimal form of data augmentation and makes the network robust to representation collapse. Then, we propose to perform structural distillation by distilling pair-wise similarities. We evaluate SimCVD on two popular datasets: the Left Atrial Segmentation Challenge (LA) and the NIH pancreas CT dataset. The results on the LA dataset demonstrate that, in two types of labeled ratios (i.e., 20% and 10%), SimCVD achieves an average Dice score of 90.85% and 89.03% respectively, a 0.91% and 2.22% improvement compared to previous best results. Our method can be trained in an end-to-end fashion, showing the promise of utilizing SimCVD as a general framework for downstream tasks, such as medical image synthesis, enhancement, and registration.

0 citations0 reviewsNo code linkedOpen access
preprint2021arXiv

Adaptive Bi-directional Attention: Exploring Multi-Granularity Representations for Machine Reading Comprehension

Recently, the attention-enhanced multi-layer encoder, such as Transformer, has been extensively studied in Machine Reading Comprehension (MRC). To predict the answer, it is common practice to employ a predictor to draw information only from the final encoder layer which generates the \textit{coarse-grained} representations of the source sequences, i.e., passage and question. Previous studies have shown that the representation of source sequence becomes more \textit{coarse-grained} from \textit{fine-grained} as the encoding layer increases. It is generally believed that with the growing number of layers in deep neural networks, the encoding process will gather relevant information for each location increasingly, resulting in more \textit{coarse-grained} representations, which adds the likelihood of similarity to other locations (referring to homogeneity). Such a phenomenon will mislead the model to make wrong judgments so as to degrade the performance. To this end, we propose a novel approach called Adaptive Bidirectional Attention, which adaptively exploits the source representations of different levels to the predictor. Experimental results on the benchmark dataset, SQuAD 2.0 demonstrate the effectiveness of our approach, and the results are better than the previous state-of-the-art model by 2.5$\%$ EM and 2.3$\%$ F1 scores.

0 citations0 reviewsNo code linkedOpen access
preprint2020arXiv

Unsupervised Wasserstein Distance Guided Domain Adaptation for 3D Multi-Domain Liver Segmentation

Deep neural networks have shown exceptional learning capability and generalizability in the source domain when massive labeled data is provided. However, the well-trained models often fail in the target domain due to the domain shift. Unsupervised domain adaptation aims to improve network performance when applying robust models trained on medical images from source domains to a new target domain. In this work, we present an approach based on the Wasserstein distance guided disentangled representation to achieve 3D multi-domain liver segmentation. Concretely, we embed images onto a shared content space capturing shared feature-level information across domains and domain-specific appearance spaces. The existing mutual information-based representation learning approaches often fail to capture complete representations in multi-domain medical imaging tasks. To mitigate these issues, we utilize Wasserstein distance to learn more complete representation, and introduces a content discriminator to further facilitate the representation disentanglement. Experiments demonstrate that our method outperforms the state-of-the-art on the multi-modality liver segmentation task.

0 citations0 reviewsNo code linkedOpen access