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Bob Zhang

Bob Zhang contributes to research discovery and scholarly infrastructure.

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Published work

4 published item(s)

preprint2026arXiv

CellScientist: Dual-Space Hierarchical Orchestration for Closed-Loop Refinement of Virtual Cell Models

Virtual Cell Modeling (VCM) requires models that not only predict perturbation responses, but also support targeted revision when predictions fail. Current LLM-assisted modeling workflows face a refinement-routing problem: prediction discrepancies are observed through executable implementations, but the relevant revision may involve the modeling assumption, representation design, implementation, or task constraint. Without structured feedback propagation across these levels, iterative refinement may repair code while failing to revise the assumption responsible for the discrepancy. We propose CellScientist, a dual-space hierarchical framework that couples a high-level hypothesis space with a low-level executable implementation space. CellScientist represents modeling decisions as structured states, realizes them as admissible programs under task and interface constraints, and routes execution discrepancies back to targeted hypothesis or implementation updates. This enables a closed Hypothesis -> Implementation -> Hypothesis loop where failures become structured signals for model refinement rather than debugging events. Across morphology and transcriptomic benchmarks, with additional single-cell perturbation evaluations, the final executable models selected by CellScientist improve over reference baselines under fixed split and evaluation protocols, while the workflow produces auditable refinement traces.

preprint2022arXiv

A Survey on Incomplete Multi-view Clustering

Conventional multi-view clustering seeks to partition data into respective groups based on the assumption that all views are fully observed. However, in practical applications, such as disease diagnosis, multimedia analysis, and recommendation system, it is common to observe that not all views of samples are available in many cases, which leads to the failure of the conventional multi-view clustering methods. Clustering on such incomplete multi-view data is referred to as incomplete multi-view clustering. In view of the promising application prospects, the research of incomplete multi-view clustering has noticeable advances in recent years. However, there is no survey to summarize the current progresses and point out the future research directions. To this end, we review the recent studies of incomplete multi-view clustering. Importantly, we provide some frameworks to unify the corresponding incomplete multi-view clustering methods, and make an in-depth comparative analysis for some representative methods from theoretical and experimental perspectives. Finally, some open problems in the incomplete multi-view clustering field are offered for researchers.

preprint2022arXiv

NFANet: A Novel Method for Weakly Supervised Water Extraction from High-Resolution Remote Sensing Imagery

The use of deep learning for water extraction requires precise pixel-level labels. However, it is very difficult to label high-resolution remote sensing images at the pixel level. Therefore, we study how to utilize point labels to extract water bodies and propose a novel method called the neighbor feature aggregation network (NFANet). Compared with pixellevel labels, point labels are much easier to obtain, but they will lose much information. In this paper, we take advantage of the similarity between the adjacent pixels of a local water-body, and propose a neighbor sampler to resample remote sensing images. Then, the sampled images are sent to the network for feature aggregation. In addition, we use an improved recursive training algorithm to further improve the extraction accuracy, making the water boundary more natural. Furthermore, our method utilizes neighboring features instead of global or local features to learn more representative features. The experimental results show that the proposed NFANet method not only outperforms other studied weakly supervised approaches, but also obtains similar results as the state-of-the-art ones.

preprint2020arXiv

Noise Homogenization via Multi-Channel Wavelet Filtering for High-Fidelity Sample Generation in GANs

In the generator of typical Generative Adversarial Networks (GANs), a noise is inputted to generate fake samples via a series of convolutional operations. However, current noise generation models merely relies on the information from the pixel space, which increases the difficulty to approach the target distribution. Fortunately, the long proven wavelet transformation is able to decompose multiple spectral information from the images. In this work, we propose a novel multi-channel wavelet-based filtering method for GANs, to cope with this problem. When embedding a wavelet deconvolution layer in the generator, the resultant GAN, called WaveletGAN, takes advantage of the wavelet deconvolution to learn a filtering with multiple channels, which can efficiently homogenize the generated noise via an averaging operation, so as to generate high-fidelity samples. We conducted benchmark experiments on the Fashion-MNIST, KMNIST and SVHN datasets through an open GAN benchmark tool. The results show that WaveletGAN has excellent performance in generating high-fidelity samples, thanks to the smallest FIDs obtained on these datasets.