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Bibhas Chakraborty

Bibhas Chakraborty contributes to research discovery and scholarly infrastructure.

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Published work

7 published item(s)

preprint2026arXiv

PFN-TS: Thompson Sampling for Contextual Bandits via Prior-Data Fitted Networks

Thompson sampling is a widely used strategy for contextual bandits: at each round, it samples a reward function from a Bayesian posterior and acts greedily under that sample. Prior-data fitted networks (PFNs), such as TabPFN v2+ and TabICL v2, are attractive candidates for this purpose because they approximate Bayesian posterior predictive distributions in a single forward pass. However, PFNs predict noisy future rewards, while Thompson sampling requires uncertainty over the latent mean reward function. We propose PFN-TS, a Thompson sampling algorithm that converts PFN posterior predictives into mean-reward samples using a subsampled predictive central limit theorem. The method estimates posterior variance from a geometric grid of $O(\log n)$ dataset prefixes rather than the full $O(n)$ predictive sequence used in previous predictive-sequence approaches, and reuses TabICL's cached representations across rounds. We prove consistency of the subsampled variance estimator and give a Bayesian regret bound that decomposes PFN-TS regret into exact posterior-sampling regret under the PFN prior plus approximation terms. Empirically, PFN-TS achieves the best average rank across nonlinear synthetic and OpenML classification-to-bandit benchmarks, remains competitive on linear and BART-generated rewards, and attains the highest estimated policy value in an offline mobile-health evaluation. Code is available at https://anonymous.4open.science/r/PFN_TS-36ED/.

preprint2026arXiv

Toward Global Large Language Models in Medicine

Despite continuous advances in medical technology, the global distribution of health care resources remains uneven. The development of large language models (LLMs) has transformed the landscape of medicine and holds promise for improving health care quality and expanding access to medical information globally. However, existing LLMs are primarily trained on high-resource languages, limiting their applicability in global medical scenarios. To address this gap, we constructed GlobMed, a large multilingual medical dataset, containing over 500,000 entries spanning 12 languages, including four low-resource languages. Building on this, we established GlobMed-Bench, which systematically assesses 56 state-of-the-art proprietary and open-weight LLMs across multiple multilingual medical tasks, revealing significant performance disparities across languages, particularly for low-resource languages. Additionally, we introduced GlobMed-LLMs, a suite of multilingual medical LLMs trained on GlobMed, with parameters ranging from 1.7B to 8B. GlobMed-LLMs achieved an average performance improvement of over 40% relative to baseline models, with a more than threefold increase in performance on low-resource languages. Together, these resources provide an important foundation for advancing the equitable development and application of LLMs globally, enabling broader language communities to benefit from technological advances.

preprint2023arXiv

Optimal Adaptive SMART Designs with Binary Outcomes

In a sequential multiple-assignment randomized trial (SMART), a sequence of treatments is given to a patient over multiple stages. In each stage, randomization may be done to allocate patients to different treatment groups. Even though SMART designs are getting popular among clinical researchers, the methodologies for adaptive randomization at different stages of a SMART are few and not sophisticated enough to handle the complexity of optimal allocation of treatments at every stage of a trial. Lack of optimal allocation methodologies can raise serious concerns about SMART designs from an ethical point of view. In this work, we develop an optimal adaptive allocation procedure to minimize the expected number of treatment failures for a SMART with a binary primary outcome. Issues related to optimal adaptive allocations are explored theoretically with supporting simulations. The applicability of the proposed methodology is demonstrated using a recently conducted SMART study named M-Bridge for developing universal and resource-efficient dynamic treatment regimes (DTRs) for incoming first-year college students as a bridge to desirable treatments to address alcohol-related risks.

preprint2022arXiv

A Novel Approach To Assess Dynamic Treatment Regimes Embedded In A Smart With An Ordinal Outcome

Sequential multiple assignment randomized trials (SMARTs) are used to construct data-driven optimal intervention strategies for subjects based on their intervention and covariate histories in different branches of health and behavioral sciences where a sequence of interventions is given to a participant. Sequential intervention strategies are often called dynamic treatment regimes (DTR). In the existing literature, the majority of the analysis methodologies for SMART data assume a continuous primary outcome. However, ordinal outcomes are also quite common in clinical practice. In this work, first, we introduce the notion of generalized odds ratio (GOR) to compare two DTRs embedded in a SMART with an ordinal outcome and discuss some combinatorial properties of this measure. Next, we propose a likelihood-based approach to estimate GOR from SMART data, and derive the asymptotic properties of its estimate. We discuss alternative ways to estimate GOR using concordant-discordant pairs and two-sample U-statistic. We derive the required sample size formula for designing SMARTs with ordinal outcomes based on GOR. A simulation study shows the performance of the estimated GOR in terms of the estimated power corresponding to the derived sample size. The methodology is applied to analyze data from the SMART+ study, conducted in the UK, to improve carbohydrate periodization behavior in athletes using a menu planner mobile application, Hexis Performance. A freely available Shiny web app using R is provided to make the proposed methodology accessible to other researchers and practitioners.

preprint2022arXiv

AutoScore-Ordinal: An interpretable machine learning framework for generating scoring models for ordinal outcomes

Background: Risk prediction models are useful tools in clinical decision-making which help with risk stratification and resource allocations and may lead to a better health care for patients. AutoScore is a machine learning-based automatic clinical score generator for binary outcomes. This study aims to expand the AutoScore framework to provide a tool for interpretable risk prediction for ordinal outcomes. Methods: The AutoScore-Ordinal framework is generated using the same 6 modules of the original AutoScore algorithm including variable ranking, variable transformation, score derivation (from proportional odds models), model selection, score fine-tuning, and model evaluation. To illustrate the AutoScore-Ordinal performance, the method was conducted on electronic health records data from the emergency department at Singapore General Hospital over 2008 to 2017. The model was trained on 70% of the data, validated on 10% and tested on the remaining 20%. Results: This study included 445,989 inpatient cases, where the distribution of the ordinal outcome was 80.7% alive without 30-day readmission, 12.5% alive with 30-day readmission, and 6.8% died inpatient or by day 30 post discharge. Two point-based risk prediction models were developed using two sets of 8 predictor variables identified by the flexible variable selection procedure. The two models indicated reasonably good performance measured by mean area under the receiver operating characteristic curve (0.785 and 0.793) and generalized c-index (0.737 and 0.760), which were comparable to alternative models. Conclusion: AutoScore-Ordinal provides an automated and easy-to-use framework for development and validation of risk prediction models for ordinal outcomes, which can systematically identify potential predictors from high-dimensional data.

preprint2022arXiv

Making SMART decisions in prophylaxis and treatment studies

The optimal prophylaxis, and treatment if the prophylaxis fails, for a disease may be best evaluated using a sequential multiple assignment randomised trial (SMART). A SMART is a multi-stage study that randomises a participant to an initial treatment, observes some response to that treatment and then, depending on their observed response, randomises the same participant to an alternative treatment. Response adaptive randomisation may, in some settings, improve the trial participants' outcomes and expedite trial conclusions, compared to fixed randomisation. But 'myopic' response adaptive randomisation strategies, blind to multistage dynamics, may also result in suboptimal treatment assignments. We propose a 'dynamic' response adaptive randomisation strategy based on Q-learning, an approximate dynamic programming algorithm. Q-learning uses stage-wise statistical models and backward induction to incorporate late-stage 'payoffs' (i.e. clinical outcomes) into early-stage 'actions' (i.e. treatments). Our real-world example consists of a COVID-19 prophylaxis and treatment SMART with qualitatively different binary endpoints at each stage. Standard Q-learning does not work with such data because it cannot be used for sequences of binary endpoints. Sequences of qualitatively distinct endpoints may also require different weightings to ensure that the design guides participants to regimens with the highest utility. We describe how a simple decision-theoretic extension to Q-learning can be used to handle sequential binary endpoints with distinct utilities. Using simulation we show that, under a set of binary utilities, the 'dynamic' approach increases expected participant utility compared to the fixed approach, sometimes markedly, for all model parameters, whereas the 'myopic' approach can actually decrease utility.

preprint2020arXiv

Multi-Level Micro-Randomized Trial: Detecting the Proximal Effect of Messages on Physical Activity

Technological advancements in mobile devices have made it possible to deliver mobile health interventions to individuals. A novel intervention framework that emerges from such advancements is the just-in-time adaptive intervention (JITAI), where it aims to suggest the right support to the individual "just in time", when their needs arise, thus having proximal, near future effects. The micro-randomized trial (MRT) design was proposed recently to test the proximal effects of these JITAIs. In an MRT, participants are repeatedly randomized to one of the intervention options of various in the intervention components, at a scale of hundreds or thousands of decision time points over the course of the study. However, the extant MRT framework only tests the proximal effect of two-level intervention components (e.g. control vs intervention). In this paper, we propose a novel version of MRT design with multiple levels per intervention component, which we call "multi-level micro-randomized trial" (MLMRT) design. The MLMRT extends the existing MRT design by allowing multi-level intervention components, and the addition of more levels to the components during the study period. We apply generalized estimating equation type methodology on the longitudinal data arising from an MLMRT to develop the novel test statistics for assessing the proximal effects and deriving the associated sample size calculators. We conduct simulation studies to evaluate the sample size calculators based on both power and precision. We have developed an R shiny application of the sample size calculators. This proposed design is motivated by our involvement in the Diabetes and Mental Health Adaptive Notification Tracking and Evaluation (DIAMANTE) study. This study uses a novel mobile application, also called "DIAMANTE", which delivers adaptive text messages to encourage physical activity.