Abstract
A rare genetic condition, PIEZO2 loss of function (LOF) is characterized by absence of proprioception and light touch, which makes functional tasks (e.g., walking, manipulation) difficult. There are no pharmacological treatments or assistive technologies available for individuals with PIEZO2-LOF. We propose a sensory substitution device that communicates proprioceptive feedback via detectable haptic stimuli. We created a wearable prototype that maps measurements of elbow movement to deep pressure applied to the forearm. The prototype applies up to 18 N, includes an embedded force sensor, and is programmable to allow for various angle-to-pressure mappings. Future work includes comparing proprioceptive acuity and movement ability with and without the device in healthy and PIEZO2-LOF individuals, developing low-profile devices using soft robotics, providing sensory substitution for multiple joints simultaneously, and encoding additional aspects of joint dynamics.
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