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Viscoelastic Properties of Vascular Endothelial Cells Exposed to Stretch

In this paper, we study how cytoskeletal remodeling is correlated to changes in subcellular microrheology. We analyze the changes in the magnitude and directionality of the shear and elastic moduli of bovine aortic endothelial cells (BAECs) exposed to cyclical, uniaxial stretch. We find that, when stretched, BAECs stiffen and align their softest direction of mechanical polarization perpendicular to stretch. We hypothesize that the response of VECs to stretch acts to minimize intracellular strain in response to stress.

preprint2013arXivOpen access
Kathryn OsterdayThomas ChewPhillip LouryJason HagaManuel Gomez-GonzalezJuan C. del AlamoShu Chien
Cell BehaviorBiological Physicscond-mat.softQuantitative Methods
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Open access7 authors4 topics
Imported metadata coverageMissing code, dataset, citation and institution fields are tracked without dominating the paper.Details
Citations: 0Reviews: 0Saves: 0Code: not linkedDataset: not linkedInstitutions: 0

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Kathryn OsterdayThomas ChewPhillip LouryJason HagaManuel Gomez-GonzalezJuan C. del AlamoShu Chien

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