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Ultrasmall Au10-12(SG)10-12 Nanomolecules for High Tumor Specificity and Cancer Radiotherapy

Radiosensitizers can increase the local treatment efficacy under a relatively low and safe radiation dose, thereby facilitating tumor eradication and minimizing side effects. Here, we report a new class of radiosensitizers that contain several gold (Au) atoms embedded inside a peptide shell (e.g., Au10-12(SG)10-12) and can achieve ultrahigh tumor uptake (10.86 SUV at 24 h post injection) and targeting specificity, efficient renal clearance, and high radiotherapy enhancement.

preprint2014arXivOpen access
Xiao-Dong ZhangZhentao LuoJie ChenXiu ShenShasha SongYuanming SunSaijun FanFeiyue FanDavid Tai LeongJianping Xie
physics.med-phBiological PhysicsTissues and Organs
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Open access10 authors3 topics
Imported metadata coverageMissing code, dataset, citation and institution fields are tracked without dominating the paper.Details
Citations: 0Reviews: 0Saves: 0Code: not linkedDataset: not linkedInstitutions: 0

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Xiao-Dong ZhangZhentao LuoJie ChenXiu ShenShasha SongYuanming SunSaijun FanFeiyue FanDavid Tai LeongJianping Xie

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