Paper detail

Ultrafast functional magnetic resonance imaging reveals neuroplasticity-driven timing modulations

Functional Magnetic Resonance Imaging (fMRI) is predominantly harnessed for spatially mapping activation foci along distributed pathways. However, resolving dynamic information on activation sequence remains elusive. Here, we show an ultra-fast fMRI (ufMRI) approach - a facilitating non-invasive methodology for mapping Blood-Oxygenation-Level-Dependent (BOLD) response timings in distributed pathways with high spatiotemporal sensitivity and resolution. The mouse visual pathway was investigated under both normal and dark reared conditions. Results show that BOLD responses of normal reared mice preserve the neural input order from onset to peak times. However, modulatory effects in cortical responses due to dark rearing are only measurable at early response timings while a general delay in responses is measured at later timings. Our findings highlight the importance of robustly measuring early BOLD timings and pave the way for a better understanding and interpretation of functional MRI in healthy and aberrant conditions.