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Paper detail

Strategies of Loop Recombination in Ciliates

Gene assembly in ciliates is an extremely involved DNA transformation process, which transforms a nucleus, the micronucleus, to another functionally different nucleus, the macronucleus. In this paper we characterize which loop recombination operations (one of the three types of molecular operations that accomplish gene assembly) can possibly be applied in the transformation of a given gene from its micronuclear form to its macronuclear form. We also characterize in which order these loop recombination operations are applicable. This is done in the abstract and more general setting of so-called legal strings.

preprint2006arXivOpen access
Robert BrijderHendrik Jan HoogeboomMichael Muskulus
Logic in Computer ScienceGenomics
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Robert BrijderHendrik Jan HoogeboomMichael Muskulus

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