Paper detail

Stability and Localization of inter-individual differences in functional connectivity

Much recent attention has been paid to quantifying anatomic and functional neuroimaging on the individual subject level. For optimal individual subject characterization, specific acquisition and analysis features need to be identified that maximize inter-individual variability while concomitantly minimizing intra-subject variability. Here we develop a non-parametric statistical metric that quantifies the degree to which a parameter set allows this individual subject differentiation. We apply this metric to analyzing publicly available test-retest resting-state fMRI (rs-fMRI) data sets. We find that for the question of maximizing individual differentiation, there is a relative tradeoff between increasing sampling through increased sampling frequency or increased acquisition time; that for the sizes of the interrogated data sets, only 4-5 min of acquisition time is necessary to perfectly differentiate each subject; and that brain regions that most contribute to individuals unique characterization lie in association cortices thought to contribute to higher cognitive function. These findings may guide optimal rs-fMRI experiment design and may aid elucidation of the neural bases for subject-to-subject differences.