Spatial Moran models I. Stochastic tunneling in the neutral case

preprint2015arXivOpen access

Abstract

We consider a multistage cancer model in which cells are arranged in a dd-dimensional integer lattice. Starting with all wild-type cells, we prove results about the distribution of the first time when two neutral mutations have accumulated in some cell in dimensions d≥2d\ge 2, extending work done by Komarova [Genetics 166 (2004) 1571-1579] for d=1d=1.

Explore this paper’s authors, topics and related work.

Building this map preview

BZPEER is loading the nearby papers, people, topics and institutions for this page.

Reviews 0

Write a reviewWrite

No reviews yet.

Discussion 0

Add a commentWrite

No comments yet.