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Spacetime and vacuum as seen from Moscow

An extended text of the talk given at the conference ``2001: A Spacetime Odyssey'', to be published in the Proceedings of the Inaugural Conference of the Michigan Center for Theoretical Physics, University of Michigan, Ann Arbor, 21-25 May 2001, M.J. Duff and J.T. Liu eds., World Scientific, Singapore, 2002; and of Historical Lecture ``Vacuum as seen from Moscow'' at the CERN Summer School, 10 August, 2001. Contents: Introduction; Pomeranchuk on vacuum; Landau on parity, P, and combined parity, CP; Search and discovery of $K_L^0 \to π^+ π^-$; "Mirror world"; Zeldovich and cosmological term; QCD vacuum condensates; Sakharov and baryonic asymmetry of the universe, BAU; Kirzhnits and phase transitions; Vacuum domain walls; Monopoles, strings, instantons, and sphalerons; False vacuum; Inflation; Brane and Bulk; Acknowledgments; References.