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Shared information between residues is sufficient to detect pair-wise epistasis in a protein

In a comment on our manuscript "Strong selection significantly increases epistatic interactions in the long-term evolution of a protein", Dr. Crona challenges our assertion that shared entropy (that is, information) between two residues implies epistasis between those residues, by constructing an explicit example of three loci (say A, B, and C), where A and B are epistatically linked (leading to shared entropy between A and B), and A and C also depend epistatically (leading to shared entropy between A and C), so that loci B and C are correlated (share entropy).

preprint2016arXivOpen access
A. GuptaC. Adami
Populations and Evolution
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Open access2 authors1 topic
Imported metadata coverageMissing code, dataset, citation and institution fields are tracked without dominating the paper.Details
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A. GuptaC. Adami

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