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Paper detail

Rosetta Brains: A Strategy for Molecularly-Annotated Connectomics

We propose a neural connectomics strategy called Fluorescent In-Situ Sequencing of Barcoded Individual Neuronal Connections (FISSEQ-BOINC), leveraging fluorescent in situ nucleic acid sequencing in fixed tissue (FISSEQ). FISSEQ-BOINC exhibits different properties from BOINC, which relies on bulk nucleic acid sequencing. FISSEQ-BOINC could become a scalable approach for mapping whole-mammalian-brain connectomes with rich molecular annotations.

preprint2014arXivOpen access
Adam H MarblestoneEvan R DaugharthyReza KalhorIan D PeikonJustus M KebschullSeth L ShipmanYuriy MishchenkoJe Hyuk LeeKonrad P KordingEdward S BoydenAnthony M ZadorGeorge M Church
Neurons and Cognition
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Adam H MarblestoneEvan R DaugharthyReza KalhorIan D PeikonJustus M KebschullSeth L ShipmanYuriy MishchenkoJe Hyuk LeeKonrad P KordingEdward S BoydenAnthony M ZadorGeorge M Church

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