Paper detail

Pregnancy as a dynamical paradox: robustness, control and birth onset

The timing of human labor is among the most critical determinants of neonatal survival, yet the mechanisms that govern the transition from uterine quiescence to coordinated contractions remain elusive. Here we present a dynamical-systems framework that models the pregnant uterus as a spatially extended network of electrically excitable cells regulated by sparse adaptive feedback mimicking hormonal and mechanical influences. This approach reveals how stability during gestation and sensitivity near parturition can be simultaneously maintained through the interplay of control, network structure, and noise. Our analysis shows that spontaneous contractions such as Braxton-Hicks and Alvarez waves are not epiphenomena, but functional components that reduce control effort and preserve responsiveness. Moreover, we identify preterm labor as a boundary-crossing phenomenon arising when control fails to correctly interpret early-warning signals. These results establish a unifying mechanistic theory for labor onset, yield testable predictions, and suggest new therapeutic strategies to mitigate preterm birth risk.