Abstract
We present the earliest astronomical observation of a high energy neutrino error box in which its variability was discovered after high-energy neutrinos detection. The one robotic telescope of the MASTER global international network (Lipunov et al. 2010) automatically imaged the error box of the very high-energy neutrino event IceCube-170922A. Observations were carried out in minute after the IceCube-170922A neutrino event was detected by the IceCube observatory at the South Pole. MASTER found the blazar TXS 0506+056 to be in the off-state after one minute and then switched to the on-state no later than two hours after the event. The effect is observed at a 50-sigma significance level. Also we present own unique 16-years light curve of blazar TXS 0506+056 (518 data set).
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