One-Way Coupled Tumor Response Model for Combined-Hyperthermia-Radiotherapy Treatment with Anisotropic Scattering

preprint2019arXivOpen access

Abstract

Therapies such as combined-hyperthermia-radiotherapy (CHR) take advantage of excellent radiosensitization properties of hyperthermia and treat of tumors with both radiation and heat. To appropriately model a CHR treatment, features like tumor heating (heat transfer), dosimetry (radiation transport), and tumor dynamics (cell population dynamics) must be considered together. Our first paper on modeling such treatments introduced a one-way coupled model that could only account for isotropic scattering of radiation. In the present work, we extend our transport model to incorporate anisotropic scattering.

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