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Multi-Messenger Astrophysics with IceCube

The cubic kilometer IceCube neutrino telescope now operating at the South Pole in a near complete configuration observes the neutrino sky with an unprecedented sensitivity to galactic and extra-galactic cosmic ray accelerators. Within the multi-messenger framework, IceCube offers unique capabilities to correlate and contrast the neutrino sky with the gamma-ray sky and ultra high energy cosmic rays and complements other indirect and direct dark matter search programs. We review here the status of the experiment and recent selected results. A discussion of the implications of the observations will be followed by the prospects of future developments, substantially extending the reach of the observatory at extremely high energies, in the GZK region and at low energies enhancing capabilities to probe dark matter and cosmic ray sources in the southern sky.