MedFM-Robust: Benchmarking Robustness of Medical Foundation Models

preprint2026arXivOpen access

Abstract

Medical foundation models (MedFMs) have emerged as transformative tools in healthcare, demonstrating capabilities across diverse clinical applications. These models can be broadly categorized into two paradigms: Medical Vision-Language Models (Med-VLMs) and segmentation foundation models. Med-VLMs range from medical-specialized models such as LLaVA-Med and MedGemma, to general-purpose models like GPT-4o and Gemini, all capable of medical image understanding tasks including visual question answering (VQA), report generation, and visual grounding. Concurrently, the Segment Anything Model (SAM) has catalyzed a new generation of medical segmentation models, with adaptations like SAM-Med2D and MedSAM. The widespread clinical deployment of these models thus necessitates rigorous evaluation of their reliability under real-world conditions.

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