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Is space-time symmetry a suitable generalization of parity-time symmetry?

We discuss space-time symmetric Hamiltonian operators of the form $% H=H_{0}+igH^{\prime}$, where $H_{0}$ is Hermitian and $g$ real. $H_{0}$ is invariant under the unitary operations of a point group $G$ while $H^{\prime}$ is invariant under transformation by elements of a subgroup $G^{\prime}$ of $G$. If $G$ exhibits irreducible representations of dimension greater than unity, then it is possible that $H$ has complex eigenvalues for sufficiently small nonzero values of $g$. In the particular case that $H$ is parity-time symmetric then it appears to exhibit real eigenvalues for all $% 0<g<g_{c}$, where $g_{c}$ is the exceptional point closest to the origin. Point-group symmetry and perturbation theory enable one to predict whether $% H $ may exhibit real or complex eigenvalues for $g>0$. We illustrate the main theoretical results and conclusions of this paper by means of two- and three-dimensional Hamiltonians exhibiting a variety of different point-group symmetries.