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Intercellular spiral waves of calcium in a two dimensional network of cells

It is shown, by means of numerical simulations, that intercellular spiral waves of calcium can be initiated in a network of coupled cells as a result of a de-synchronization between Ca2+ oscillations in two domains. No artificial heterogeneities need to be imposed to the system for spontaneous formation of spiral waves. The de-synchronization occurs near the interface of the stimulated region (which acts as a pacemaker) and propagates over the entire network. We also find the outcome of the collision of two spiral waves.

preprint2010arXivOpen access
Wilfred D. KepseuPaul WoafoH. Sakaguchi
Cell BehaviorBiological PhysicsMolecular NetworksBiomolecules
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Wilfred D. KepseuPaul WoafoH. Sakaguchi

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