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Inferring the flow properties of epithelial tissues from their geometry

Amorphous materials exhibit complex material proprteties with strongly nonlinear behaviors. Below a yield stress they behave as plastic solids, while they start to yield above a critical stress $Σ_c$. A key quantity controlling plasticity which is, however, hard to measure is the density $P(x)$ of weak spots, where $x$ is the additional stress required for local plastic failure. In the thermodynamic limit $P(x)\sim x^θ$ is singular at $x= 0$ in the solid phase below the yield stress $Σ_c$. This singularity is related to the presence of system spannig avalanches of plastic events. Here we address the question if the density of weak spots and the flow properties of a material can be determined from the geometry of an amporphous structure alone. We show that a vertex model for cell packings in tissues exhibits the phenomenology of plastic amorphous systems. As the yield stress is approached from above, the strain rate vanishes and the avalanches size $S$ and their duration $τ$ diverge. We then show that in general, in materials where the energy functional depend on topology, the value $x$ is proportional to the length $L$ of a bond that vanishes in a plastic event. For this class of models $P(x)$ is therefore readily measurable from geometry alone. Applying this approach to a quantification of the cell packing geometry in the developing wing epithelium of the fruit fly, we find that in this tissue $P(L)$ exhibits a power law with exponents similar to those found numerically for a vertex model in its solid phase. This suggests that this tissue exhibits plasticity and non-linear material properties that emerge from collective cell behaviors and that these material properties govern developmental processes. Our approach based on the relation between topology and energetics suggests a new route to outstanding questions associated with the yielding transition.