Improved Rank-Modulation Codes for DNA Storage with Shotgun Sequencing

We study permutations over the set of $\ell$-grams, that are feasible in the sense that there is a sequence whose $\ell$-gram frequency has the same ranking as the permutation. Codes, which are sets of feasible permutations, protect information stored in DNA molecules using the rank-modulation scheme, and read using the shotgun sequencing technique. We construct systematic codes with an efficient encoding algorithm, and show that they are optimal in size. The length of the DNA sequences that correspond to the codewords is shown to be polynomial in the code parameters. Non-systematic with larger size are also constructed.

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