Global stability in a competitive infection-age structured model

preprint2020arXivOpen access

Abstract

We study a competitive infection-age structured SI model between two diseases. The well-posedness of the system is handled by using integrated semigroups theory, while the existence and the stability of disease-free or endemic equilibria are ensured, depending on the basic reproduction number R0xR_0^x and R0yR_0^y of each strain. We then exhibit Lyapunov functionals to analyse the global stability and we prove that the disease-free equilibrium is globally asymptotically stable whenever max⁡{R0x,R0y}≤1\max\{R_0^x, R_0^y\}\leq 1. With respect to explicit basin of attraction, the competitive exclusion principle occurs in the case where R0x≠R0yR_0^x\neq R_0^y and max⁡{R0x,R0y}>1\max\{R_0^x,R_0^y\}>1, meaning that the strain with the largest R0R_0 persists and eliminates the other strain. In the limit case R0x=Ry0>1R_0^x=R^0_y>1, an infinite number of endemic equilibria exists and constitute a globally attractive set.

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