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Enhanced Tumor Accumulation of Sub-2 nm Gold Nanoclusters for Cancer Radiation Therapy

A new type of metabolizable and efficient radiosensitizer for cancer radiotherapy is presented in this study by combining ultrasmall Au nanoclusters (NCs, <2 nm) with biocompatible coating ligands (glutathione, GSH). The new nano-construct (GSH-coated Au25 NCs) inherits attractive features of both the Au core (strong radiosensitizing effect) and GSH shell (good biocompatibility). It can preferentially accumulate in tumor via the improved EPR effect, which leads to strong enhancement for cancer radiotherapy. After the treatment, the small-sized GSH-Au25 NCs can be efficiently cleared by the kidney, minimizing any potential side effects due to the accumulation of Au25 NCs in the body.

preprint2013arXivOpen access
Xiao-Dong ZhangJie ChenZhentao LuoDi WuXiu ShenSha-Sha SongYuan-Ming SunPei-Xun LiuJing ZhaoShuaidong HuoSaijun FanFeiyue FanXing-Jie LiangJianping Xie
physics.med-phBiological Physics
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Open access14 authors2 topics
Imported metadata coverageMissing code, dataset, citation and institution fields are tracked without dominating the paper.Details
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Xiao-Dong ZhangJie ChenZhentao LuoDi WuXiu ShenSha-Sha SongYuan-Ming SunPei-Xun LiuJing ZhaoShuaidong HuoSaijun FanFeiyue FanXing-Jie LiangJianping Xie

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