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Counterion Effects on Nano-confined Metal-Drug-DNA Complexes

We have explored morphology of DNA molecules bound with Cu-complexes of piroxicam molecules, a non-steroidal anti-inflammatory drug (NSAID), under one-dimensional confinement of thin films and have studied the effect of counterions present in a buffer. X-ray reflectivity at and away from the Cu K absorption edge and atomic force microscopy studies reveal that confinement segregates the drug molecules preferentially in a top layer of the DNA film, and counterions enhance this segregation.

preprint2016arXivOpen access
Nupur BiswasSreeja ChakrabortyAlokmay DattaMunna SarkarMrinmay K. MukhopadhyayMrinal K. BeraHideki Seto
cond-mat.mes-hallBiological Physicscond-mat.soft
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Open access7 authors3 topics
Imported metadata coverageMissing code, dataset, citation and institution fields are tracked without dominating the paper.Details
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Nupur BiswasSreeja ChakrabortyAlokmay DattaMunna SarkarMrinmay K. MukhopadhyayMrinal K. BeraHideki Seto

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