Paper detail

Cellular wrapping of elastic particles by a supported lipid membrane

Constancy of life vitally depends on the internalization of particles through biomembranes. Of particular interest, cellular uptake, including phagocytosis, receptor-mediated endocytosis, and membrane fusion, critically depends on the elasticity of particles. Cellular membranes are strongly linked to a supporting cytoskeleton. However, in most previous studies, the effect of this cortical network somehow is overlooked. In this paper, we study the cellular wrapping of a membrane around a 2D elastic particle in the presence of a substrate mimicking cytoskeleton. Our simulations show that the impact of particle flexibility on the wrapping process depends on the magnitude of the membrane particle adhesion. In contrast, the extent of membrane protrusions formed around the target always increases with target stiffness. Since the extension of membrane protrusions is an essential step in the phagocytosis process, this result may indicate a selective behavior of macrophages in the phagocytosis of aged red blood cells.