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A waiting time problem arising from the study of multi-stage carcinogenesis

We consider the population genetics problem: how long does it take before some member of the population has $m$ specified mutations? The case $m=2$ is relevant to onset of cancer due to the inactivation of both copies of a tumor suppressor gene. Models for larger $m$ are needed for colon cancer and other diseases where a sequence of mutations leads to cells with uncontrolled growth.

preprint2009arXivOpen access
Rick DurrettDeena SchmidtJason Schweinsberg
math.PRTissues and Organs
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Open access3 authors2 topics
Imported metadata coverageMissing code, dataset, citation and institution fields are tracked without dominating the paper.Details
Citations: 0Reviews: 0Saves: 0Code: not linkedDataset: not linkedInstitutions: 0

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Rick DurrettDeena SchmidtJason Schweinsberg

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