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A Self-Replicating Peptide Nucleic Acid

We report on a case of autocatalytic feedback in a template directed synthesis of a self-complementary hexa-PNA from two trimeric building blocks. The course of the reaction was monitored in the presence of increasing initial concentrations of product by means of RP-HPLC. Kinetic modeling with the SimFit program revealed parabolic growth according to the so-called square-root law. The observed template effect, as well as the rate of the ligation, was significantly influenced by factors like nucleophilic catalysts, pH value, and uncharged co-solvents. Systematic optimization of the reaction conditions allowed us to increase the autocatalytic efficiency of the system by two orders of magnitude.

preprint2011arXivOpen access
Tobias A. PlögerGünter von Kiedrowski
Molecular NetworksPopulations and Evolution
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Tobias A. PlögerGünter von Kiedrowski

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