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Paper detail

A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues

We model a general, hierarchically organized tissue by a multi compartment approach, allowing any number of mutations within a cell. We derive closed solutions for the deterministic clonal dynamics and the reproductive capacity of single clones. Our results hold for the average dynamics in a hierarchical tissue characterized by an arbitrary combination of proliferation parameters.

preprint2013arXivOpen access
B. WernerD. DingliA. Traulsen
Populations and Evolution
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B. WernerD. DingliA. Traulsen

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