Abstract
For a skew-symmetrizable cluster algebra with principal coefficients at , we prove that each seed of is uniquely determined by its {\bf C-matrix}, which was proposed by Fomin and Zelevinsky in \cite{FZ3} as a conjecture. Our proof is based on the fact that the positivity of cluster variables and sign-coherence of -vectors hold for , which was actually verified in \cite{GHKK}. More discussion is given in the sign-skew-symmetric case so as to obtain a conclusion as weak version of the conjecture in this general case.
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