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The formation of a hot deconfined medium (Quark-Gluon Plasma) in high-energy nuclear collisions affects heavy-flavor observables. In the low/moderate-pT range transport calculations allow one to simulate the propagation of heavy quarks in the plasma and to evaluate the effect of the medium on the final hadronic spectra: results obtained with transport coefficients arising from different theoretical approaches can be compared to experimental data. Finally, a discussion of possible effects on heavy-flavor observables due to the possible formation of a hot-medium in small systems (like in p-A collisions) is presented.
preprint / 2015