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Fan Xia

Fan Xia contributes to research discovery and scholarly infrastructure.

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Published work

3 published item(s)

preprint2026arXiv

TTE-Flash: Accelerating Reasoning-based Multimodal Representations via Think-Then-Embed Tokens

Recent research has demonstrated that Universal Multimodal Embedding (UME) benefits significantly from Chain-of-Thought (CoT) reasoning. In this paradigm, a generative model produces explicit reasoning traces for a multimodal query, with the final representation extracted from an <eos> embedding token attending to both the query and the reasoning. Despite its effectiveness, the computational overhead of generating explicit CoT traces is often prohibitive. In this work, we propose replacing explicit CoT with latent think tokens, which are interpreted as latent variables that can produce explicit CoT traces as observed variables. By optimizing think tokens using CoT generation loss and subsequent embedding tokens using contrastive loss, we produce high-performance, reasoning-aware representations at a constant inference cost. Our study investigates two key architectural designs: 1) how think and embeddings tokens should be extracted from the same LLM backbone. 2) how the tokens should be trained as two dependent tasks. We introduce TTE-Flash-2B, a reasoning-aware multimodal representation model that outperforms its explicit-CoT counterpart on the MMEB-v2 benchmark, while producing latent think tokens that are interpretable both textually and visually. Furthermore, zero-shot evaluation across 15 video datasets reveals scaling behavior as the number of think tokens increases, and motivating a pilot study of adaptive think budget allocation based on task requirements.

preprint2022arXiv

First implementation of full-workflow automation in radiotherapy: the All-in-One solution on rectal cancer

The aim of this work is to describe the technical characteristics of an AI-powered radiotherapy workflow that enables full-process automation (All-in-One), evaluate its performance implemented for on-couch initial treatment of rectal cancer, and provide insight into the behavior of full-workflow automation in the specialty of radiotherapy. The All-in-One workflow was developed based on a CT-integrated linear accelerator. It incorporates routine radiotherapy procedures from simulation, autosegmentation, autoplanning, image guidance, beam delivery, and in vivo quality assurance (QA) into one scheme, with critical decision points involved, while the patient is on the treatment couch during the whole process. For the enrolled ten patients with rectal cancer, minor modifications of the autosegmented target volumes were required, and the Dice similarity coefficient and 95% Hausdorff distance before and after modifications were 0.892{\pm}0.061 and 18.2{\pm}13.0 mm, respectively. The autosegmented normal tissues and automatic plans were clinically acceptable without any modifications or reoptimization. The pretreatment IGRT corrections were within 2 mm in all directions, and the EPID-based in vivo QA showed a γ passing rate better than 97{\%} (3{\%}/3 mm/10{\%} threshold). The duration of the whole process was 23.2{\pm}3.5 minutes, depending mostly on the time required for manual modification and plan evaluation. The All-in-One workflow enables full automation of the entire radiotherapy process by seamlessly integrating multiple routine procedures. The one-stop solution shortens the time scale it takes to ready the first treatment from days to minutes, significantly improving the patient experience and the efficiency of the workflow, and shows potential to facilitate the clinical application of online adaptive replanning.

preprint2021arXiv

Defining and Estimating Subgroup Mediation Effects with Semi-Competing Risks Data

In many medical studies, an ultimate failure event such as death is likely to be affected by the occurrence and timing of other intermediate clinical events. Both event times are subject to censoring by loss-to-follow-up but the nonterminal event may further be censored by the occurrence of the primary outcome, but not vice versa. To study the effect of an intervention on both events, the intermediate event may be viewed as a mediator, but conventional definition of direct and indirect effects is not applicable due to semi-competing risks data structure. We define three principal strata based on whether the potential intermediate event occurs before the potential failure event, which allow proper definition of direct and indirect effects in one stratum whereas total effects are defined for all strata. We discuss the identification conditions for stratum-specific effects, and proposed a semiparametric estimator based on a multivariate logistic stratum membership model and within-stratum proportional hazards models for the event times. By treating the unobserved stratum membership as a latent variable, we propose an EM algorithm for computation. We study the asymptotic properties of the estimators by the modern empirical process theory and examine the performance of the estimators in numerical studies.