Researcher profile

C. Manuel Carlevaro

C. Manuel Carlevaro contributes to research discovery and scholarly infrastructure.

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Published work

4 published item(s)

preprint2026arXiv

Confinement-controlled chase-escape dynamics

We investigate a minimal chase-and-escape model on a two-dimensional square lattice with randomly distributed static obstacles, focusing on how geometric disorder controls collective pursuit dynamics. Chasers and escapers move according to short-range sensing rules, while the density of obstacles tunes the connectivity of the accessible space. Using a combination of geometric analysis, dynamical observables, survival statistics, and transport characterization, we establish a direct link between lattice connectivity and pursuit efficiency. A Breadth-First Search analysis reveals that obstacle-induced fragmentation leads to a progressive loss of accessibility before the percolation threshold, defining the effective initial conditions for the dynamics. The trapping time and capture cost exhibit a non-monotonic dependence on obstacle density, reflecting a competition between path elongation in connected environments and geometric confinement near the percolation threshold. Survival analysis shows that the decay of the escaper population follows a Weibull form, with characteristic time and shape parameters displaying clear crossovers as a function of obstacle density, signaling the coexistence of cooperative capture and confinement-dominated trapping. Transport properties, quantified through the mean-squared displacement exponent, further support this picture, revealing sub-diffusive dynamics and a convergence toward a geometry-controlled regime near percolation. Overall, our results demonstrate that chase--and--escape dynamics in disordered environments are governed by a geometry-driven crossover, where percolation and connectivity act as unifying control parameters for spatial, temporal, and collective behavior.

preprint2026arXiv

Molecular Mechanisms of Urea Interactions with Bovine Serum Albumin in an Acid-Expanded Conformation (pH 3.7)

Understanding the molecular mechanism by which denaturants modulate protein structure remains a central challenge in protein biophysics. In this work, molecular dynamics simulations were employed to investigate the effects of urea on the structural stability of bovine serum albumin, its F isoform at pH 3.7, over a broad range of urea concentrations (0 M to a fully urea/solvated system). The results reveal that urea induces a concentration/dependent dehydration/rehydration mechanism within the protein hydration shell. At low urea concentrations, a marked reduction in protein/water hydrogen bonds is observed, accompanied by a corresponding increase in protein/urea interactions, consistent with a competitive solvation process. At higher concentrations, urea/urea self-association becomes significant, limiting direct protein/urea interactions and promoting partial rehydration of the protein surface. Despite these solvent rearrangements, the secondary structure of BSA remains largely preserved, whereas local and tertiary structural features, particularly in Domain III, exhibit increased solvent exposure and conformational flexibility. These findings support a dynamic compensation mechanism in which urea partially replaces water in the solvation shell without fully disrupting the hydrogen-bonding network. Overall, this study provides molecular-level insight into the interplay between preferential interactions, solvation dynamics, and protein stability under denaturing conditions.

preprint2019arXiv

Intruder in a two-dimensional granular system: Effects of dynamic and static basal friction on stick-slip and clogging dynamics

We discuss the results of simulations of an intruder pulled through a two-dimensional granular system by a spring, using a model designed to lend insight into the experimental findings described by Kozlowski et al. [Phys. Rev. E, 100, 032905 (2019)]. In that previous study the presence of basal friction between the grains and the base was observed to change the intruder dynamics from clogging to stick-slip. Here we first show that our simulation results are in excellent agreement with the experimental data for a variety of experimentally accessible friction coefficients governing interactions of particles with each other and with boundaries. Then, we use simulations to explore a broader range of parameter space, focusing on the friction between the particles and the base. We consider a range of both static and dynamic basal friction coefficients, which are difficult to vary smoothly in experiments. The simulations show that dynamic friction strongly affects the stick-slip behaviour when the coefficient is decreased below 0.1, while static friction plays only a marginal role in the intruder dynamics.

preprint2019arXiv

Microwave Tomography with phaseless data on the calcaneus by means of artificial neural networks

The aim of this study is to use a Multilayer Perceptron (MLP) Artificial Neural Network (ANN) for phaseless imaging the human heel (modeled as a bilayer dielectric media: bone and surrounding tissue) and the calcaneus cross-section size and location using a two dimensional (2D) microwave tomographic array. Computer simulations were performed over 2D dielectric maps inspired by Computed Tomography (CT) images of human heels for training and testing the MLP. A morphometric analysis was performed to account for the scatterer shape influence on the results. A robustness analysis was also conducted in order to study the MLP performance in noisy conditions. The standard deviations of the relative percentage errors on estimating the dielectric properties of the calcaneus bone were relatively high. Regarding the calcaneus surrounding tissue, the dielectric parameters estimations are better, with relative percentage error standard deviations up to $\approx$ 15 %. The location and size of the calcaneus are always properly estimated with absolute error standard deviations up to $\approx $ 3 mm.